Paralogue Annotation for KCNE1 residue 25

Residue details

Gene: KCNE1
Reference Sequences: LRG: LRG_290, Ensembl variant: ENST00000399289 / ENSP00000382228
Amino Acid Position: 25
Reference Amino Acid: G - Glycine
Protein Domain: N-terminus

Paralogue Variants mapped to KCNE1 residue 25

No paralogue variants have been mapped to residue 25 for KCNE1.

KCNE1	-NTTAVTPFLTKLWQE---T------VQQG>G<N-MSGLA-RRSPRSSDGKLEALYVLMVLGF	53
KCNE2	-FTQTLEDVFRRIFITYMDNW----RQNTT>A<EQEALQA-KVDAENFY--YVILYLMVMIGM	59
KCNE3	TWYESLHAVLKALNATLHSNLLCRPGPGLG>P<D-NQTEERRASLPGR-DDNSYMYILFVMFL	67
KCNE4	-----------MLKMEPLNST----HPGTA>A<SSSPLES-RAAGGGSGNGNEYFYILVVMSF	45
cons	> <

See full Alignment of Paralogues

Known Variants in KCNE1

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.G25V	c.74G>T	Inherited Arrhythmia	AF		SIFT: Polyphen:
Reports		Inherited Arrhythmia	AF	Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation. BMC Med Genet. 2012 13:24. 22471742