Paralogue Annotation for KCNE1 residue 60

Residue details

Gene: KCNE1
Reference Sequences: LRG: LRG_290, Ensembl variant: ENST00000399289 / ENSP00000382228
Amino Acid Position: 60
Reference Amino Acid: G - Glycine
Protein Domain: Transmembrane region


Paralogue Variants mapped to KCNE1 residue 60

No paralogue variants have been mapped to residue 60 for KCNE1.



KCNE1A-RRSPRSSDGKLEALYVLMVLGFFGFFTL>G<IMLSYIRSKKLEHSNDPFNVYIESDA-WQE89
KCNE2A-KVDAENFY--YVILYLMVMIGMFSFIIV>A<ILVSTVKSKRREHSNDPYHQYIVED--WQE94
KCNE3ERRASLPGR-DDNSYMYILFVMFLFAVTVG>S<LILGYTRSRKVDKRSDPYHVYIKN------98
KCNE4S-RAAGGGSGNGNEYFYILVVMSFYGIFLI>G<IMLGYMKSKRREKKSSLLLLYKDEERLWGE82
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNE1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.G60Dc.179G>A Inherited ArrhythmiaAFSIFT:
Polyphen:
ReportsInherited ArrhythmiaAF Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation. BMC Med Genet. 2012 13:24. 22471742