No paralogue variants have been mapped to residue 1021 for KCNH2.
| KCNH2 | ---------------RQYQELPRCPAPTP->S<LLN----IPL-SSPGRRPRGDV-ESRLDAL | 1045 |
| KCNH1 | ------------------KSEDWNKVSKA->E<SME----TLP-E------RTKA-S-----G | 870 |
| KCNH3 | ---------------PKFSFRVGQSGPE-->C<SSSPSPGPES-G----LLTVPH-GPSEARN | 874 |
| KCNH4 | ---------------PSFRFSRRPELPRP->R<SQA----PPT-GTRP-SPELAS-EAEEVK- | 877 |
| KCNH5 | ---------------HEEKKEDWNNVTKA->E<SMG----LLS-EDPKSSDSENS-V-----T | 854 |
| KCNH6 | ---------------QGHASYILEAPASN->D<LAL----VPI-ASETTSPGPRL-P------ | 889 |
| KCNH7 | ---------------SALQRAAWGISET-->-<-------------ESDLTYGEV-EQRLDLL | 1038 |
| KCNH8 | ---------------QTFDFGSERIRSEP->R<ISP-----PLGDPEIGAAVLFI-KAEETK- | 864 |
| CNGA1 | --------------------------T--->-<------------------------------ | 690 |
| CNGA2 | --------------------------P--->-<------------------------------ | 664 |
| CNGA3 | --------------------------Q--->-<------------------------------ | 694 |
| CNGA4 | ---------------GRASQEGPPGPE--->-<------------------------------ | 575 |
| CNGB1 | ---------------PRTPPEPP------->-<-G------SP-PSSPPPAS----------- | 1204 |
| CNGB3 | ---------------GREPEEKPLDRPECT>A<-S------PI-AVEEEPHS----------- | 769 |
| HCN1 | -QQ-------------VQQSQPPQTQPQQP>S<-PQPQTPG---S--STPKNEVH-KSTQALH | 775 |
| HCN2 | -A-P-------------ASPRAPR-----T>S<--------------PYGGLPAAPLAGPALP | 809 |
| HCN3 | -PP----------ARTLHASLSRAGRSQ-V>S<LLG--PP---------P----------GGG | 701 |
| HCN4 | RGGLSPPGHSPGPPRTFPSAPPRASGSH-G>S<LLL--PPASS-P--PPPQVPQR-RGTPPLT | 1075 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.S1021T | c.3062G>C | Putative Benign | SIFT: tolerated Polyphen: benign |