Paralogue Annotation for KCNH2 residue 1110

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1110
Reference Amino Acid: Q - Glutamine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1110

No paralogue variants have been mapped to residue 1110 for KCNH2.



KCNH2PGPTSTSPLL-----PVSPLP-TLTLDSLS>Q<VSQFMACEELPPGAPELPQ-----------1129
KCNH1LQATVLEVRH-----ELKEDIKALNAKMTN>I<EKQLSEILRILTSRRS--------------963
KCNH3--GEGPCPASTSGLLQPLCVDTGASSYCLQ>P<PAGSVLSGTWPHPRPGPPPL--MAPWPWG-978
KCNH4WTPDPPCPQL-----RP-----PCLSPCAS>R<PPPSLQDTTLAEVH-CPASV--GTMETG--968
KCNH5LQTTLQEVKH-----ELKEDIQLLSCRMTA>L<EKQVAEILKILSEKSVPQ------------949
KCNH6TLAPSSEQEQ-----PEGLWP-PLASPLHP>L<EVQGLICG----------------------960
KCNH7TSQPEASIKT-----DRSFSPSSQCPEFLD>L<EKSKLKSKESLSSGVHLNTA--SEDNLTSL1143
KCNH8WSAHQPCLHL-----QTGGAAYTQAQLCSS>N<ITSDIWSVDPSSVGSSPQRT--GAHEQNPA981
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1RPEGEEEGPA-----EPEEHSVRIC----->-<------------------------------1226
CNGB3R----TVLPR-----GTSRQSLIIS----->-<------------------------------787
HCN1--G---RST--------------VP-QRVT>L<FRQMSSGAIP------PNRGVPPAPP----861
HCN2--S---ST-------------PRLG-P--->-<-------------TP-AARAAAPSPD----862
HCN3--G---SE-------------R-LP-PSGL>L<-------AKP------PRTAQPPRPP----758
HCN4--S---GGLG-----PPGRPYGAIPGQHVT>L<PRKTSSGSLPPPLSLFGARATSSGGP----1178
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.Q1110Pc.3329A>C Putative BenignSIFT:
Polyphen: