Paralogue Annotation for KCNH2 residue 169

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 169
Reference Amino Acid: A - Alanine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 169

No paralogue variants have been mapped to residue 169 for KCNH2.



KCNH2------TNHRGPPTSWLAPGRAKTFRLKLP>A<LLALTARESSVRSGGAGGAGAPGAVVVDVD199
KCNH1---------------------CKGWG---->-<------------------------------149
KCNH3---------------------WKETGGGRR>-<------------------------------153
KCNH4---------------------GRGDSNHEN>-<------------------------------154
KCNH5---------------------TKGWT---->-<------------------------------147
KCNH6----------------LAKCSSRSLSQRLL>S<QSFLGSEGSHGRPGGPG-------------167
KCNH7-------N----PILPIKTVNRKFFGFKFP>G<LRVLTYRKQSLPQEDPD------VVVIDS-187
KCNH8------------------------DKKEDK>-<------------------------------149
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1LDSCVVSQVGVGQSEEDGTRPQSTSDQKLW>E<EVGEEAKKEAEEKAKEEAEEVAEEEAEKEP437
CNGB3-----------SRRNEEGSHPSNQSQQ--->-<TTAQEENKGEEKSLKTKSTPVTSEEPHTNI69
HCN1---------------------PAGG---F->-<------------------------------81
HCN2---------------------EAGSEEAG->-<------------------------------150
HCN3----------------------------G->-<------------------------------41
HCN4----------------------AAGDQIL->-<------------------------------201
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.A169Gc.506C>G Inherited ArrhythmiaLQTSSIFT:
Polyphen:
ReportsInherited ArrhythmiaLQTS Common Genotypes of Long QT Syndrome in China and the Role of ECG Prediction. Cardiology. 2016 133(2):73-8. doi: 10.1159/000440608. 26496715