Paralogue Annotation for KCNH2 residue 331

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 331
Reference Amino Acid: S - Serine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 331

No paralogue variants have been mapped to residue 331 for KCNH2.



KCNH2STGAMHPLRSGLLNSTSDSDLVRYR---TI>S<KIPQITLNFVDLKGDPFLASP-T-SDREII359
KCNH1----------------------KFA----->-<------------RLTRALTSS-R-GVLQQL168
KCNH3-----------------------S------>-<-----------KGFNANRRRS-R-AVLYHL177
KCNH4-----------------------A------>-<----------TWKFRSARRRS-R-TVLHRL179
KCNH5----------------------KFA----->-<------------RLTRALTNS-R-SVLQQL166
KCNH6------------------TGRGKYR---TI>S<QIPQFTLNFVEFNLEKHRSSS-T-TEIEII207
KCNH7VKGPFNHIKSSLLGSTSDSNLNKYS---TI>N<KIPQLTLNFSEVKTEKKNSSPPS-SDKTII359
KCNH8-----------------------A------>-<----------GTHFDSARRRS-R-AVLYHI174
CNGA1------------------------------>-<--------KKK-KKKEKKSKS-D-DKNENK123
CNGA2------------------------------>-<--------FLE-RFRGPELQT-V-TTQEGD112
CNGA3------------------------------>-<--------FPD-RFRGAELKE-V-SSQESN116
CNGA4------------------------------>-<-----------------KVKT-T-ES----12
CNGB1RAASTASTNSAIINDRLQELVKLFKERTEK>V<-KEKLIDPDVTSDEE-SPKPSPA-KKAPEP609
CNGB3--PPAAPVINEYADAQLHNLVKRMRQRTAL>Y<-KKKLVEGDLSS-----PEASPQ-TAKPTA169
HCN1------------------------------>-<------------EDAEGPR-R-QYGFMQRQ97
HCN2------------------------------>-<------------PAGEPRG-S-QASFMQRQ166
HCN3------------------------------>-<------------PE------P-----KRRH48
HCN4------------------------------>-<------------PEAEVRL-G-QAGFMQRQ217
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.S331Nc.992G>A Putative BenignSIFT:
Polyphen: