Paralogue Annotation for KCNH2 residue 357

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 357
Reference Amino Acid: E - Glutamate
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 357

No paralogue variants have been mapped to residue 357 for KCNH2.



KCNH2TISKIPQITLNFVDLKGDPFLASP-T-SDR>E<II-AP-KIK-E--R-THNV-TEKVTQVL--378
KCNH1---------------RLTRALTSS-R-GVL>Q<QL-APS-VQKG--E-NVHK-HSRLAEVL--188
KCNH3--------------KGFNANRRRS-R-AVL>Y<HL-SGH-LQK---Q-PKG--KHKLNKGV--195
KCNH4-------------TWKFRSARRRS-R-TVL>H<RL-TGH-FGR---R-GQG--GMKANNNV--197
KCNH5---------------RLTRALTNS-R-SVL>Q<QL-TPM-NKT---E-VVHK-HSRLAEVL--185
KCNH6TISQIPQFTLNFVEFNLEKHRSSS-T-TEI>E<II-APHKVV-E--R-TQNV-TEKVTQVL--227
KCNH7TINKIPQLTLNFSEVKTEKKNSSPPS-SDK>T<II-AP-KVK-D--R-THNV-TEKVTQVL--378
KCNH8-------------GTHFDSARRRS-R-AVL>Y<HI-SGH-LQR---R-EKN--KLKINNNV--192
CNGA1-----------KKK-KKKEKKSKS-D-DKN>E<NKNDPE-KK------------K-KKKD-KE136
CNGA2-----------FLE-RFRGPELQT-V-TTQ>E<GDGKG--D----------------------116
CNGA3-----------FPD-RFRGAELKE-V-SSQ>E<SNAQ-A-NVGS--QEPADRGRS-AWPLAKC139
CNGA4--------------------KVKT-T-ES->-<------------------------------12
CNGB1EKV-KEKLIDPDVTSDEE-SPKPSPA-KKA>P<EP-APD-TKPAEAE-PVEE-EHYCDMLC--631
CNGB3ALY-KKKLVEGDLSS-----PEASPQ-TAK>P<TA-VPP-VKES--D-DKPT-EHYYRLLW--189
HCN1---------------EDAEGPR-R-QYGFM>Q<RQ--FT-SM----L-QPGV-NKF-SLRM--113
HCN2---------------PAGEPRG-S-QASFM>Q<RQ--FG-AL----L-QPGV-NKF-SLRM--182
HCN3---------------PE------P-----K>R<RH--LG-TL----L-QPTV-NKF-SLRV--64
HCN4---------------PEAEVRL-G-QAGFM>Q<RQ--FG-AM----L-QPGV-NKF-SLRM--233
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.E357Dc.1071G>T Putative BenignSIFT:
Polyphen: