Paralogue Annotation for KCNH2 residue 435

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 435
Reference Amino Acid: E - Glutamate
Protein Domain: Transmembrane/Linker/Pore


Paralogue Variants mapped to KCNH2 residue 435

No paralogue variants have been mapped to residue 435 for KCNH2.



KCNH2FKA-VWDWLILLLVIYTAVFTPYSAAFLLK>E<TEEGPPATECGYACQPLAVVDLIVDIMFIV465
KCNH1FKT-TWDWIILILTFYTAILVPYNVSFKTR>Q<N------------NVAWLVVDSIVDVIFLV263
KCNH3LRA-TWDGFILLATLYVAVTVPYSVCVSTA>R<E--------PSAARGPPSVCDLAVEVLFIL274
KCNH4SKA-IWDGLILLATFYVAVTVPYNVCFSGD>D<D--------TPITSRHTLVSDIAVEMLFIL276
KCNH5FKT-TWDWVILILTFYTAIMVPYNVSFKTK>Q<N------------NIAWLVLDSVVDVIFLV260
KCNH6FKA-VWDWLILLLVIYTAVFTPYSAAFLLS>D<QDE-SRRGACSYTCSPLTVVDLIVDIMFVV313
KCNH7FKA-VWDWLILLLVIYTAIFTPYSAAFLLN>D<REE-QKRRECGYSCSPLNVVDLIVDIMFII464
KCNH8FKA-GWDWLILLATFYVAVTVPYNVCFIGN>D<D--------LS-TTRSTTVSDIAVEILFII270
CNGA1TYY-NWLFCITLPVMYNWTMVIARACFDEL>Q<S----------DYLEYWLILDYVSDIVYLI213
CNGA2WYY-CWLFVIAMPVLYNWCLLVARACFSDL>Q<K----------GYYLVWLVLDYVSDVVYIA188
CNGA3LYY-RWLTAIALPVFYNWYLLICRACFDEL>Q<S----------EYLMLWLVLDYSADVLYVL216
CNGA4YYY-WWLNTMVFPVMYNLIILVCRACFPDL>Q<H----------GYLVAWLVLDYTSDLLYLL82
CNGB1LMYVLWLFFVVMAWNWNCWLIPVRWAFPYQ>T<P----------DNIHHWLLMDYLCDLIYFL704
CNGB3RLYLLWLLLVTLAYNWNCCFIPLRLVFPYQ>T<A----------DNIHYWLIADIICDIIYLY266
HCN1FRF-YWDLIMLIMMVGNLVIIPVGITFFTE>Q<T------------TTPWIIFNVASDTVFLL188
HCN2FRF-YWDFTMLLFMVGNLIIIPVGITFFKD>E<T------------TAPWIVFNVVSDTFFLM257
HCN3FRF-YWDLIMLLLMVGNLIVLPVGITFFKE>E<N------------SPPWIVFNVLSDTFFLL139
HCN4FRF-YWDLTMLLLMVGNLIIIPVGITFFKD>E<N------------TTPWIVFNVVSDTFFLI308
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.E435Gc.1304A>G Putative BenignSIFT:
Polyphen: