Paralogue Annotation for KCNH2 residue 443

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 443
Reference Amino Acid: T - Threonine
Protein Domain: Transmembrane/Linker/Pore


Paralogue Variants mapped to KCNH2 residue 443

No paralogue variants have been mapped to residue 443 for KCNH2.



KCNH2LILLLVIYTAVFTPYSAAFLLKETEEGPPA>T<ECGYACQPLAVVDLIVDIMFIVDI-LINFR472
KCNH1IILILTFYTAILVPYNVSFKTRQN------>-<-----NVAWLVVDSIVDVIFLVDI-VLNFH270
KCNH3FILLATLYVAVTVPYSVCVSTARE------>-<-PSAARGPPSVCDLAVEVLFILDI-VLNFR281
KCNH4LILLATFYVAVTVPYNVCFSGDDD------>-<-TPITSRHTLVSDIAVEMLFILDI-ILNFR283
KCNH5VILILTFYTAIMVPYNVSFKTKQN------>-<-----NIAWLVLDSVVDVIFLVDI-VLNFH267
KCNH6LILLLVIYTAVFTPYSAAFLLSDQDE-SRR>G<ACSYTCSPLTVVDLIVDIMFVVDI-VINFR320
KCNH7LILLLVIYTAIFTPYSAAFLLNDREE-QKR>R<ECGYSCSPLNVVDLIVDIMFIIDI-LINFR471
KCNH8LILLATFYVAVTVPYNVCFIGNDD------>-<-LS-TTRSTTVSDIAVEILFIIDI-ILNFR277
CNGA1CITLPVMYNWTMVIARACFDELQS------>-<---DYLEYWLILDYVSDIVYLIDM-FVRTR220
CNGA2VIAMPVLYNWCLLVARACFSDLQK------>-<---GYYLVWLVLDYVSDVVYIADL-FIRLR195
CNGA3AIALPVFYNWYLLICRACFDELQS------>-<---EYLMLWLVLDYSADVLYVLDV-LVRAR223
CNGA4TMVFPVMYNLIILVCRACFPDLQH------>-<---GYLVAWLVLDYTSDLLYLLDM-VVRFH89
CNGB1FVVMAWNWNCWLIPVRWAFPYQTP------>-<---DNIHHWLLMDYLCDLIYFLDITVFQTR712
CNGB3LVTLAYNWNCCFIPLRLVFPYQTA------>-<---DNIHYWLIADIICDIIYLYDMLFIQPR274
HCN1IMLIMMVGNLVIIPVGITFFTEQT------>-<-----TTPWIIFNVASDTVFLLDL-IMNFR195
HCN2TMLLFMVGNLIIIPVGITFFKDET------>-<-----TAPWIVFNVVSDTFFLMDL-VLNFR264
HCN3IMLLLMVGNLIVLPVGITFFKEEN------>-<-----SPPWIVFNVLSDTFFLLDL-VLNFR146
HCN4TMLLLMVGNLIIIPVGITFFKDEN------>-<-----TTPWIVFNVVSDTFFLIDL-VLNFR315
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.T443Nc.1328C>A Putative BenignSIFT:
Polyphen: