Paralogue Annotation for KCNH2 residue 487

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 487
Reference Amino Acid: G - Glycine
Protein Domain: Transmembrane/Linker/Pore


Paralogue Variants mapped to KCNH2 residue 487

No paralogue variants have been mapped to residue 487 for KCNH2.



KCNH2VDIMFIVDI-LINFRTTYVN-ANEEVVSHP>G<RIAVHYFKGW-FLIDMVAAIPFDLLIFGSG516
KCNH1VDVIFLVDI-VLNFHTTFVG-PAGEVISDP>K<LIRMNYLKTW-FVIDLLSCLPYDVINAFEN314
KCNH3VEVLFILDI-VLNFRTTFVS-KSGQVVFAP>K<SICLHYVTTW-FLLDVIAALPFDLLHAF-K324
KCNH4VEMLFILDI-ILNFRTTYVS-QSGQVISAP>R<SIGLHYLATW-FFIDLIAALPFDLLYIF-N326
KCNH5VDVIFLVDI-VLNFHTTFVG-PGGEVISDP>K<LIRMNYLKTW-FVIDLLSCLPYDIINAFEN311
KCNH6VDIMFVVDI-VINFRTTYVN-TNDEVVSHP>R<RIAVHYFKGW-FLIDMVAAIPFDLLIFRTG364
KCNH7VDIMFIIDI-LINFRTTYVN-QNEEVVSDP>A<KIAIHYFKGW-FLIDMVAAIPFDLLIFGSG515
KCNH8VEILFIIDI-ILNFRTTYVS-KSGQVIFEA>R<SICIHYVTTW-FIIDLIAALPFDLLYAF-N320
CNGA1SDIVYLIDM-FVRTRTGYLE--QGLLVKEE>L<KLINKYKSNLQFKLDVLSLIPTDLLYFKLG264
CNGA2SDVVYIADL-FIRLRTGFLE--QGLLVKDT>K<KLRDNYIHTLQFKLDVASIIPTDLIYFAVD239
CNGA3ADVLYVLDV-LVRARTGFLE--QGLMVSDT>N<RLWQHYKTTTQFKLDVLSLVPTDLAYLKVG267
CNGA4SDLLYLLDM-VVRFHTGFLE--QGILVVDK>G<RISSRYVRTWSFFLDLASLMPTDVVYVRLG133
CNGB1CDLIYFLDITVFQTRLQFVR--GGDIITDK>K<DMRNNYLKSRRFKMDLLSLLPLDFLYLKVG756
CNGB3CDIIYLYDMLFIQPRLQFVR--GGDIIVDS>N<ELRKHYRTSTKFQLDVASIIPFDICYLFFG318
HCN1SDTVFLLDL-IMNFRTGTVNEDSSEIILDP>K<VIKMNYLKSW-FVVDFISSIPVDYIFLIVE240
HCN2SDTFFLMDL-VLNFRTGIVIEDNTEIILDP>E<KIKKKYLRTW-FVVDFVSSIPVDYIFLIVE309
HCN3SDTFFLLDL-VLNFRTGIVVEEGAEILLAP>R<AIRTRYLRTW-FLVDLISSIPVDYIFLVVE191
HCN4SDTFFLIDL-VLNFRTGIVVEDNTEIILDP>Q<RIKMKYLKSW-FMVDFISSIPVDYIFLIVE360
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.G487Sc.1459G>A Putative BenignSIFT: tolerated
Polyphen: benign