Paralogue Annotation for KCNH2 residue 499

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 499
Reference Amino Acid: L - Leucine
Protein Domain: Transmembrane/Linker/Pore


Paralogue Variants mapped to KCNH2 residue 499

No paralogue variants have been mapped to residue 499 for KCNH2.



KCNH2FRTTYVN-ANEEVVSHPGRIAVHYFKGW-F>L<IDMVAAIPFDLLIFGSGSEE----------519
KCNH1FHTTFVG-PAGEVISDPKLIRMNYLKTW-F>V<IDLLSCLPYDVINAFENVDEVSAFMGDPGK327
KCNH3FRTTFVS-KSGQVVFAPKSICLHYVTTW-F>L<LDVIAALPFDLLHAF-KVN-----------326
KCNH4FRTTYVS-QSGQVISAPRSIGLHYLATW-F>F<IDLIAALPFDLLYIF-NIT-----------328
KCNH5FHTTFVG-PGGEVISDPKLIRMNYLKTW-F>V<IDLLSCLPYDIINAFENVDEG---------315
KCNH6FRTTYVN-TNDEVVSHPRRIAVHYFKGW-F>L<IDMVAAIPFDLLIFRTGSDE----------367
KCNH7FRTTYVN-QNEEVVSDPAKIAIHYFKGW-F>L<IDMVAAIPFDLLIFGSGSDE----------518
KCNH8FRTTYVS-KSGQVIFEARSICIHYVTTW-F>I<IDLIAALPFDLLYAF-NVT-----------322
CNGA1TRTGYLE--QGLLVKEELKLINKYKSNLQF>K<LDVLSLIPTDLLYFKLGWNY----------267
CNGA2LRTGFLE--QGLLVKDTKKLRDNYIHTLQF>K<LDVASIIPTDLIYFAVDIHS----------242
CNGA3ARTGFLE--QGLMVSDTNRLWQHYKTTTQF>K<LDVLSLVPTDLAYLKVGTNY----------270
CNGA4FHTGFLE--QGILVVDKGRISSRYVRTWSF>F<LDLASLMPTDVVYVRLGPHT----------136
CNGB1TRLQFVR--GGDIITDKKDMRNNYLKSRRF>K<MDLLSLLPLDFLYLKVGVN-----------758
CNGB3PRLQFVR--GGDIIVDSNELRKHYRTSTKF>Q<LDVASIIPFDICYLFFGFN-----------320
HCN1FRTGTVNEDSSEIILDPKVIKMNYLKSW-F>V<VDFISSIPVDYIFLIVEK--GMDSEVYKTA251
HCN2FRTGIVIEDNTEIILDPEKIKKKYLRTW-F>V<VDFVSSIPVDYIFLIVEK--GIDSEVYKTA320
HCN3FRTGIVVEEGAEILLAPRAIRTRYLRTW-F>L<VDLISSIPVDYIFLVVELEPRLDAEVYKTA204
HCN4FRTGIVVEDNTEIILDPQRIKMKYLKSW-F>M<VDFISSIPVDYIFLIVET--RIDSEVYKTA371
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.Leu499Argc.1496T>G UnknownSIFT:
Polyphen: