Paralogue Annotation for KCNH2 residue 656

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 656
Reference Amino Acid: F - Phenylalanine
Protein Domain: Transmembrane/Linker/Pore


Paralogue Variants mapped to KCNH2 residue 656

No paralogue variants have been mapped to residue 656 for KCNH2.



KCNH2GFGNVSPNTNSEKIFSICVMLIGSLMYASI>F<GNVSAIIQRLYSGTARYHTQMLRVREFIRF686
KCNH1GFGNIAPSTDIEKIFAVAIMMIGSLLYATI>F<GNVTTIFQQMYANTNRYHEMLNSVRDFLKL525
KCNH3GFGNVSANTDTEKIFSICTMLIGALMHAVV>F<GNVTAIIQRMYARRFLYHSRTRDLRDYIRI527
KCNH4GFGNVCANTDAEKIFSICTMLIGALMHAVV>F<GNVTAIIQRMYSRRSLYHSRMKDLKDFIRV501
KCNH5GFGNIAPTTDVEKMFSVAMMMVGSLLYATI>F<GNVTTIFQQMYANTNRYHEMLNNVRDFLKL494
KCNH6GFGNVSPNTNSEKVFSICVMLIGSLMYASI>F<GNVSAIIQRLYSGTARYHTQMLRVKEFIRF538
KCNH7GFGNVSPNTNSEKIFSICVMLIGSLMYASI>F<GNVSAIIQRLYSGTARYHMQMLRVKEFIRF689
KCNH8GFGNVSANTDAEKIFSICTMLIGALMHALV>F<GNVTAIIQRMYSRWSLYHTRTKDLKDFIRV496
CNGA1G-ETPPPVRDSEYVFVVVDFLIGVLIFATI>V<GNIGSMISNMNAARAEFQARIDAIKQYMHF423
CNGA2G-ETPPPVKDEEYLFVIFDFLIGVLIFATI>V<GNVGSMISNMNATRAEFQAKIDAVKHYMQF398
CNGA3G-ETPPPVKDEEYLFVVVDFLVGVLIFATI>V<GNVGSMISNMNASRAEFQAKIDSIKQYMQF426
CNGA4G-DTPPPAREEEYLFMVGDFLLAVMGFATI>M<GSMSSVIYNMNTADAAFYPDHALVKKYMKL292
CNGB1G-GLPDPKTLFEIVFQLLNYFTGVFAFSVM>I<GQMRDVVGAATAGQTYYRSCMDSTVKYMNF906
CNGB3G-GLPEPQTLFEIVFQLLNFFSGVFVFSSL>I<GQMRDVIGAATANQNYFRACMDDTIAYMNN468
HCN1GYGAQAPVSMSDLWITMLSMIVGATCYAMF>V<GHATALIQSLDSSRRQYQEKYKQVEQYMSF420
HCN2GYGRQAPESMTDIWLTMLSMIVGATCYAMF>I<GHATALIQSLDSSRRQYQEKYKQVEQYMSF489
HCN3GYGQQAPVGMPDVWLTMLSMIVGATCYAMF>I<GHATALIQSLDSSRRQYQEKYKQVEQYMSF373
HCN4GYGRQAPVGMSDVWLTMLSMIVGATCYAMF>I<GHATALIQSLDSSRRQYQEKYKQVEQYMSF540
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.F656Cc.1967T>G Inherited ArrhythmiaLQTSSIFT: deleterious
Polyphen: probably damaging
ReportsInherited ArrhythmiaLQTS Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice. JAMA. 2005 294(23):2975-80. 16414944