Paralogue Annotation for KCNH2 residue 840

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 840
Reference Amino Acid: E - Glutamate
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 840

No paralogue variants have been mapped to residue 840 for KCNH2.



KCNH2-P----GKSNGDVRALTYCDLHKIHRDDLL>E<VLDMYPEFSDHFWSSL--EIT-FNLRDTNM867
KCNH1-L----AQSCANVRALTYCDLHVIKRDALQ>K<VLEFYTAFSHSFSRNL--ILT-YNLRKRIV706
KCNH3-V----VKANADVKGLTYCVLQCLQLAGLH>D<SLALYPEFAPRFSRGLRGELS-YNLGAGGG709
KCNH4ADPNFVLKTSADVKALTYCGLQQLSSRGLA>E<VLRLYPEYGAAFRAGLPRDLT-FNLRQGSD693
KCNH5-L----AHACANVRALTYCDLHIIKREALL>K<VLDFYTAFANSFSRNL--TLT-CNLRKRII675
KCNH6-P----GKSSADVRALTYCDLHKIQRADLL>E<VLDMYPAFAESFWSKL--EVT-FNLRDAAG719
KCNH7-P----GKSNADVRALTYCDLHKIQREDLL>E<VLDMYPEFSDHFLTNL--ELT-FNLRHESA870
KCNH8-V----IKTNADVKALTYCDLQCIILKGLF>E<VLDLYPEYAHKFVEDIQHDLT-YNLREGHE678
CNGA1-G----NRRTANIKSIGYSDLFCLSKDDLM>E<ALTEYPDAKTMLEEKGKQILMKDGLLDLNI613
CNGA2-G----NRRTANIRSLGYSDLFCLSKDDLM>E<AVTEYPDAKKVLEERGREILMKEGLLDENE588
CNGA3-G----NRRTANIRSIGYSDLFCLSKDDLM>E<ALTEYPEAKKALEEKGRQILMKDNLIDEEL616
CNGA4-G----NRRTANIKSLGYSDLFCLSKEDLR>E<VLSEYPQAQTIMEEKGREILLKMNKLDVNA482
CNGB1-G----NRRTANVVAHGFTNLFILDKKDLN>E<ILVHYPESQKLLRKKARRMLRSNNKPK---1091
CNGB3-G----NRRTANVVAHGFANLLTLDKKTLQ>E<ILVHYPDSERILMKKARVLLKQKAKTA-EA655
HCN1-------RRTASVRADTYCRLYSLSVDNFN>E<VLEEYPMMRRAFETVAIDRLDRIGKKNSIL601
HCN2-------RRTASVRADTYCRLYSLSVDNFN>E<VLEEYPMMRRAFETVAIDRLDRIGKKNSIL670
HCN3-------RRTASVRADTYCRLYSLSVDHFN>A<VLEEFPMMRRAFETVAMDRLLRIGKKNSIL554
HCN4-------RRTASVRADTYCRLYSLSVDNFN>E<VLEEYPMMRRAFETVALDRLDRIGKKNSIL721
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.E840Qc.2518G>C Putative BenignSIFT:
Polyphen: