Paralogue Annotation for KCNH2 residue 92

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 92
Reference Amino Acid: R - Arginine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 92

No paralogue variants have been mapped to residue 92 for KCNH2.



KCNH2-------------------------GAEE->R<-------KVE-IAFYRK-----------DG103
KCNH1-------------------------NYEM->N<-------SFE-ILMYKK-----------NR104
KCNH3-------------------------EHKE->F<-------KAE-LILYRK-----------SG104
KCNH4-------------------------GHQE->H<-------RAE-ICFYRK-----------DG104
KCNH5-------------------------NYES->N<-------CFE-VLLYKK-----------NR102
KCNH6-------------------------GAEE->C<-------KVD-ILYYRK-----------DA103
KCNH7-------------------------GSEE->R<-------KVE-VTYYHK-----------NG103
KCNH8-------------------------EKTE->F<-------KGE-IMFYKK-----------NG104
CNGA1-------------------------EDDD->S<ASTSEESENEN-PHA-R-----------GS65
CNGA2-------------------------AADDD>T<SSE---------LQR-L-----------AD55
CNGA3-------------------------SSEE->T<SSVLQPGIAME-TRG-L-----------AD59
CNGA4------------------------------>-<------------------------------
CNGB1-------------------------AQDT->R<-------PGLRLLLWLEQNLERVLPQPPKS176
CNGB3------------------------------>-<------------------------------
HCN1KASATGAGPAAAEKRLGTPPGGGGAGAKE->H<-------GNS-VCFKVD-------------62
HCN2AASTAKGSPNGECGRGEPQCSPAGPEGPA->R<-------GPK-VSFSCR-------------128
HCN3------------------------------>-<------------APPPA-------------30
HCN4QPAS-------------------------->-<-------------ASCE-------------180
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.R92Cc.274C>T Putative BenignSIFT: tolerated
Polyphen: possibly damaging
p.Arg92Leuc.275G>T UnknownSIFT:
Polyphen: