No paralogue variants have been mapped to residue 109 for KCNQ1.
| KCNQ1 | ---------------------------VQG>R<VYNFLERPT-GWKCFVYHFAVFLIVLVCLI | 138 |
| KCNQ2 | ---------------------------LQN>F<LYNVLERPR-G-WAFIYHAYVFLLVFSCLV | 108 |
| KCNQ3 | ---------------------------IQT>L<IYDALERPR-G-WALLYHALVFLIVLGCLI | 138 |
| KCNQ4 | ---------------------------LQN>W<VYNVLERPR-G-WAFVYHVFIFLLVFSCLV | 114 |
| KCNQ5 | ---------------------------VQN>Y<LYNVLERPR-G-WAFIYHAFVFLLVFGCLI | 142 |
| KCNA1 | ----------------------P-EKEYQR>Q<VWLLFEYPESSGPARVIAIVSVMVILISIV | 182 |
| KCNA10 | ----------------------P-TNDIHR>Q<FWLLFEYPESSSAARAVAVVSVLVVVISIT | 231 |
| KCNA2 | ----------------------P-ENEFQR>Q<VWLLFEYPESSGPARIIAIVSVMVILISIV | 178 |
| KCNA3 | ----------------------P-RRDFQR>Q<VWLLFEYPESSGPARGIAIVSVLVILISIV | 249 |
| KCNA4 | ----------------------P-ENEFKK>Q<IWLLFEYPESSSPARGIAIVSVLVILISIV | 322 |
| KCNA5 | ----------------------P-RNEFQR>Q<VWLIFEYPESSGSARAIAIVSVLVILISII | 265 |
| KCNA6 | ----------------------P-SQPFQR>Q<VWLLFEYPESSGPARGIAIVSVLVILISIV | 189 |
| KCNA7 | ----------------------P-RRAFAR>Q<LWLLFEFPESSQAARVLAVVSVLVILVSIV | 158 |
| KCNB1 | ----------F-------DNTC--CAEKRK>K<LWDLLEKPNSSVAAKILAIISIMFIVLSTI | 204 |
| KCNB2 | ----------F-------DNTC--CPDKRK>K<LWDLLEKPNSSVAAKILAIVSILFIVLSTI | 208 |
| KCNC1 | SDS-----PDG-------RPGGF-WRRWQP>R<IWALFEDPYSSRYARYVAFASLFFILVSIT | 205 |
| KCNC2 | EDAAGLGGPDG-------KSGR--WRRLQP>R<MWALFEDPYSSRAARFIAFASLFFILVSIT | 244 |
| KCNC3 | QDAG--GGAGGPPGGAGGAGGTW-WRRWQP>R<VWALFEDPYSSRAARYVAFASLFFILISIT | 305 |
| KCNC4 | HEGG--AGHGA-------GSGG--CRGWQP>R<MWALFEDPYSSRAARVVAFASLFFILVSIT | 241 |
| KCND1 | ----------------------PAGSSLRQ>R<LWRAFENPHTSTAALVFYYVTGFFIAVSVI | 201 |
| KCND2 | ----------------------PTMT-ARQ>R<VWRAFENPHTSTMALVFYYVTGFFIAVSVI | 200 |
| KCND3 | ----------------------PSLS-FRQ>T<MWRAFENPHTSTLALVFYYVTGFFIAVSVI | 198 |
| KCNF1 | ----------A-------AEGR--WRRCQK>C<VWKFLEKPESSCPARVVAVLSFLLILVSSV | 197 |
| KCNG1 | ----------E-------GEGRL-GR-CMR>R<LRDMVERPHSGLPGKVFACLSVLFVTVTAV | 242 |
| KCNG2 | ----------G-------PRGRL-QR-GRR>R<LRDVVDNPHSGLAGKLFACVSVSFVAVTAV | 192 |
| KCNG3 | ----------G-------AEAAP-SRRWLE>R<MRRTFEEPTSSLAAQILASVSVVFVIVSMV | 186 |
| KCNG4 | ----------S-------HSSRW-GL-CMN>R<LREMVENPQSGLPGKVFACLSILFVATTAV | 236 |
| KCNS1 | ----------Y-------GAAR--CGRLRR>R<LWLTMENPGYSLPSKLFSCVSISVVLASIA | 235 |
| KCNS2 | ----------F-------DGQP--LGNFRR>Q<LWLALDNPGYSVLSRVFSILSILVVMGSII | 202 |
| KCNS3 | ----------F-------DTLR--FGQLRK>K<IWIRMENPAYCLSAKLIAISSLSVVLASIV | 200 |
| KCNV1 | ----------F-------SQGP--CPTVRQ>K<LWNILEKPGSSTAARIFGVISIIFVVVSII | 225 |
| KCNV2 | ----------F-------RDMRF-YGPQRR>R<LWNLMEKPFSSVAAKAIGVASSTFVLVSVV | 275 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.R109L | c.326G>T | Putative Benign | SIFT: Polyphen: |