No paralogue variants have been mapped to residue 249 for KCNQ1.
| KCNQ1 | GQVFATSAIRGIRFLQILRMLHVDRQGGTW>R<LLGSVVFIHRQELITTLYIGFLGLIFSSYF | 279 |
| KCNQ2 | GNVFATSALRSLRFLQILRMIRMDRRGGTW>K<LLGSVVYAHSKELVTAWYIGFLCLILASFL | 249 |
| KCNQ3 | GNVLA-TSLRSLRFLQILRMLRMDRRGGTW>K<LLGSAICAHSKELITAWYIGFLTLILSSFL | 278 |
| KCNQ4 | GNIFATSALRSMRFLQILRMVRMDRRGGTW>K<LLGSVVYAHSKELITAWYIGFLVLIFASFL | 255 |
| KCNQ5 | GNIFATSALRSLRFLQILRMVRMDRRGGTW>K<LLGSVVYAHSKELITAWYIGFLVLIFSSFL | 283 |
| KCNA1 | EQATSLAILRVIRLVRVFRIFKLSRHSKGL>Q<ILGQTLKASMRELGLLIFFLFIGVILFSSA | 343 |
| KCNA10 | QQNMSLAILRIIRLVRVFRIFKLSRHSKGL>Q<ILGQTLKASMRELGLLIFFLFIGVILFSSA | 392 |
| KCNA2 | QQAMSLAILRVIRLVRVFRIFKLSRHSKGL>Q<ILGQTLKASMRELGLLIFFLFIGVILFSSA | 345 |
| KCNA3 | QQAMSLAILRVIRLVRVFRIFKLSRHSKGL>Q<ILGQTLKASMRELGLLIFFLFIGVILFSSA | 415 |
| KCNA4 | QQAMSFAILRIIRLVRVFRIFKLSRHSKGL>Q<ILGHTLRASMRELGLLIFFLFIGVILFSSA | 495 |
| KCNA5 | QQAMSLAILRVIRLVRVFRIFKLSRHSKGL>Q<ILGKTLQASMRELGLLIFFLFIGVILFSSA | 451 |
| KCNA6 | QQAMSLAILRVIRLVRVFRIFKLSRHSKGL>Q<ILGKTLQASMRELGLLIFFLFIGVILFSSA | 393 |
| KCNA7 | QQAMSLAILRVIRLVRVFRIFKLSRHSKGL>Q<ILGQTLRASMRELGLLIFFLFIGVVLFSSA | 329 |
| KCNB1 | QFQNVRRVVQIFRIMRILRILKLARHSTGL>Q<SLGFTLRRSYNELGLLILFLAMGIMIFSSL | 348 |
| KCNB2 | QFQNVRRVVQIFRIMRILRILKLARHSTGL>Q<SLGFTLRRSYNELGLLILFLAMGIMIFSSL | 352 |
| KCNC1 | AAKDVLGFLRVVRFVRILRIFKLTRHFVGL>R<VLGHTLRASTNEFLLLIIFLALGVLIFATM | 362 |
| KCNC2 | AAKDVLGFLRVVRFVRILRIFKLTRHFVGL>R<VLGHTLRASTNEFLLLIIFLALGVLIFATM | 399 |
| KCNC3 | AAKDVLGFLRVVRFVRILRIFKLTRHFVGL>R<VLGHTLRASTNEFLLLIIFLALGVLIFATM | 465 |
| KCNC4 | AARDVLGFLRVVRFVRILRIFKLTRHFVGL>R<VLGHTLRASTNEFLLLIIFLALGVLIFATM | 398 |
| KCND1 | KNDDVSGAFVTLRVFRVFRIFKFSRHSQGL>R<ILGYTLKSCASELGFLLFSLTMAIIIFATV | 343 |
| KCND2 | DNEDVSGAFVTLRVFRVFRIFKFSRHSQGL>R<ILGYTLKSCASELGFLLFSLTMAIIIFATV | 341 |
| KCND3 | NNEDVSGAFVTLRVFRVFRIFKFSRHSQGL>R<ILGYTLKSCASELGFLLFSLTMAIIIFATV | 338 |
| KCNF1 | ELTNVQQAVQALRIMRIARIFKLARHSSGL>Q<TLTYALKRSFKELGLLLMYLAVGIFVFSAL | 341 |
| KCNG1 | YLDKVGLVLRVLRALRILYVMRLARHSLGL>Q<TLGLTARRCTREFGLLLLFLCVAIALFAPL | 394 |
| KCNG2 | LLERAGLVLRLLRALRVLYVMRLARHSLGL>R<SLGLTMRRCAREFGLLLLFLCVAMALFAPL | 339 |
| KCNG3 | QLQRAGVTLRVLRMMRIFWVIKLARHFIGL>Q<TLGLTLKRCYREMVMLLVFICVAMAIFSAL | 340 |
| KCNG4 | YLEKVGLVLRVLRALRILYVMRLARHSLGL>Q<TLGLTVRRCTREFGLLLLFLAVAITLFSPL | 388 |
| KCNS1 | EFGHLGKVVQVFRLMRIFRVLKLARHSTGL>R<SLGATLKHSYREVGILLLYLAVGVSVFSGV | 393 |
| KCNS2 | TLANLGRVAQVLRLMRIFRILKLARHSTGL>R<SLGATLKYSYKEVGLLLLYLSVGISIFSVV | 346 |
| KCNS3 | DIENMGKVVQILRLMRIFRILKLARHSVGL>R<SLGATLRHSYHEVGLLLLFLSVGISIFSVL | 341 |
| KCNV1 | ELENVGRIVQVLRLLRALRMLKLGRHSTGL>R<SLGMTITQCYEEVGLLLLFLSVGISIFSTV | 363 |
| KCNV2 | SVGKVGQVLRVMRLMRIFRILKLARHSTGL>R<AFGFTLRQCYQQVGCLLLFIAMGIFTFSAA | 428 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.R249K | c.746G>A | Putative Benign | rs371956290 | SIFT: tolerated Polyphen: possibly damaging |