Paralogue Annotation for KCNQ1 residue 27

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 27
Reference Amino Acid: S - Serine
Protein Domain: N-terminus

Paralogue Variants mapped to KCNQ1 residue 27

No paralogue variants have been mapped to residue 27 for KCNQ1.

KCNQ1	------------------------------>S<----------------------------A-	28
KCNQ2	--------P-SG--E--KKLKV-------G>F<VGLD-----PGA---------------PD-	33
KCNQ3	-------AA-AG--D--EERKVGLAPGDVE>Q<VTLA-----------------------LG-	58
KCNQ4	--------P-PP--G--DAPRA-------E>-<LVAL-----------------------TA-	28
KCNQ5	--------M-KD--V--ESGRG-------R>-<VLLN-----------------------SA-	51
KCNA1	--D-------GSYPRQ-A-D--HDDHECCE>R<VVINI-------------------------	43
KCNA10	-------------------------NEGNQ>R<VIINI-------------------------	92
KCNA2	--D-------TYDP-E-------ADHECCE>R<VVINI-------------------------	39
KCNA3	RYE-------PLPPSL-PAA--GEQDCCGE>R<VVINI-------------------------	110
KCNA4	--D-------EGGGGY-S-S--VRYSDCCE>R<VVINV-------------------------	182
KCNA5	--EE-GDPGLGTVEDQ-A-L--GTASLHHQ>R<VHINI-------------------------	126
KCNA6	----------------------GGGCCSSE>R<LVINI-------------------------	47
KCNA7	-----------------------PPCGCCE>R<LVLNV-------------------------	19
KCNB1	-------TSSLPPEPM-E-I--VRSKACSR>R<VRLNV-------------------------	37
KCNB2	-------TLSLPPEPV-D-I--IRSKTCSR>R<VKINV-------------------------	41
KCNC1	----------------------MGQGDESE>R<IVINVGGTRHQTYRSTLRTLPGTRLAWLAE	39
KCNC2	----------------------MGKIENNE>R<VILNVGGTRHETYRSTLKTLPGTRLALLAS	39
KCNC3	--AEPCPGL-P-AAAMGR-H--GGGGGDSG>K<IVINVGGVRHETYRSTLRTLPGTRLAGLTE	119
KCNC4	--K-------T---CLKE-E--MAKGEASE>K<IIINVGGTRHETYRSTLRTLPGTRLAWLAD	67
KCND1	------------PPAP-G-V--KAS-RGDE>V<LVVNV-------------------------	46
KCND2	------------PAPP-R-Q--ERKRTQDA>L<IVLNV-------------------------	47
KCND3	------------PLAP-A-D--KNK-RQDE>L<IVLNV-------------------------	46
KCNF1	-----------LPEPG-S-Q--SSAASDDI>E<IVVNV-------------------------	29
KCNG1	--RR-AQRLRPQDEPR-Q-G--CQPEDRRR>R<IIINV-------------------------	69
KCNG2	--------------------------TRAR>H<VIINV-------------------------	23
KCNG3	-----G-------------------RSGAA>S<VVLNV-------------------------	15
KCNG4	--RR-VRK-----VGA-L-D--ASPVDLKK>E<ILINV-------------------------	65
KCNS1	--ST-ETFVSEFPGPD-T-G--IRWRRSDE>A<LRVNV-------------------------	56
KCNS2	-------------------V--SEANVEDG>E<IRINV-------------------------	23
KCNS3	----------------------HRPGQDEE>L<VNLNV-------------------------	21
KCNV1	--SL-TSLDSSVFCSE-G-E--GEPLALGD>C<FTVNV-------------------------	45
KCNV2	--DQ-QAGEVTTAKPE-G-P--SDPPALLS>T<LNVNV-------------------------	103
cons	> <

See full Alignment of Paralogues

Known Variants in KCNQ1

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.Ser27Arg	c.81C>A	Unknown			SIFT: Polyphen: