Paralogue Annotation for KCNQ1 residue 459

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 459
Reference Amino Acid: D - Aspartate
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 459

No paralogue variants have been mapped to residue 459 for KCNQ1.



KCNQ1MLTVPHITCDPPEERRL--------DHFSV>D<GYDSSVRKSPTLLEV---SM----------476
KCNQ2SPQAQTVRRSPSADQSLED-SPSKVPKSW->-<SFGDRSRARQAF------RIKG--------500
KCNQ3--------FTPLNVDAIEE-SPSKEPKPV->-<GLNNKERFRTAF------RMKA--------480
KCNQ4HLAPPTMPTSPSSEQVGEATSPTKVQKSW->-<SFNDRTRFRASL------RLK---------498
KCNQ5--ASVGDRRSPSTDITAEG-SPTKVQKSW->-<SFNDRTRFRPSL------RLKS--------481
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1QGSPEK-------ARSSSSPQH-----L-->-<------------NVQQLEDMYNKMAKTQ--540
KCNB2QEVSQKDSHEQLNNTSSSSPQH-----L-->-<------------SAQKLEMLYNEITKTQPH553
KCNC1------------------------------>-<------------------------------
KCNC2------------------------------>-<------------------------------
KCNC3------------------------------>-<------------------------------
KCNC4------------------------------>-<------------------------------
KCND1--------------F------------T-->-<------------DEL---------------497
KCND2--------------F------------V-->-<------------DEQ---------------497
KCND3--------------F------------I-->-<------------DEQ---------------514
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.D459Nc.1375G>A Putative BenignSIFT:
Polyphen: