Paralogue Annotation for KCNQ1 residue 466

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 466
Reference Amino Acid: R - Arginine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 466

No paralogue variants have been mapped to residue 466 for KCNQ1.



KCNQ1TCDPPEERRL--------DHFSVDGYDSSV>R<KSPTLLEV---SM-----------------476
KCNQ2RRSPSADQSLED-SPSKVPKSW--SFGDRS>R<ARQAF------RIKG---------------500
KCNQ3-FTPLNVDAIEE-SPSKEPKPV--GLNNKE>R<FRTAF------RMKA---------------480
KCNQ4PTSPSSEQVGEATSPTKVQKSW--SFNDRT>R<FRASL------RLK----------------498
KCNQ5RRSPSTDITAEG-SPTKVQKSW--SFNDRT>R<FRPSL------RLKS------------S--482
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1------ARSSSSPQH-----L--------->-<-----NVQQLEDMYNKMAKTQ--SQPILNT547
KCNB2SHEQLNNTSSSSPQH-----L--------->-<-----SAQKLEMLYNEITKTQPHSHPNPDC560
KCNC1------------------------------>-<------------------------------
KCNC2------------------------------>-<------------------------------
KCNC3------------------------------>-<------------------------------
KCNC4------------------------------>-<------------------------------
KCND1-------F------------T--------->-<-----DEL----------------------497
KCND2-------F------------V--------->-<-----DEQ----------------------497
KCND3-------F------------I--------->-<-----DEQ----------------------514
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.R466Gc.1396A>G Other Cardiac PhenotypeSIFT:
Polyphen:
ReportsOther Cardiac Phenotype Cardiac channelopathy testing in 274 ethnically diverse sudden unexplained deaths. Forensic Sci Int. 2014 237:90-9. doi: 10.1016/j.forsciint.2014.01.014. 24631775