Paralogue Annotation for KCNQ1 residue 495

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 495
Reference Amino Acid: T - Threonine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 495

No paralogue variants have been mapped to residue 495 for KCNQ1.



KCNQ1---------------------------EGE>T<----------------LLTPITHISQLREH509
KCNQ2---------------------------VDD>K<----------------SCPCEFVTEDLTPG535
KCNQ3---------------------------AED>R<----------------GYGNDFPIEDMIPT514
KCNQ4---------------------------AEE>K<----------------SYQCELTVDDIMPA529
KCNQ5---------------------------YDE>K<----------------GCQCDVSVEDLTPP517
KCNA1------------------------------>-<------------------TAN----CTTAN482
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------TAN----CTLAN486
KCNA3------------------------------>-<------------------TAT----CTTNN560
KCNA4------------------------------>-<------------------GDD----SETDK640
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<--------------------------P---516
KCNA7------------------------------>-<------------------------------
KCNB1STAPEVGW-RGALGASGG----RF--VEAN>-<------PSPDASQHSSFFIESPKSSMKTNN665
KCNB2PPFLTLSREKGPAAR-DGTLEYAPVDITVN>L<DASGSQCGLHSPLQSDNATDSPKSSLKGSN708
KCNC1------------------------------>-<----------------LTPDEGLPFTRSGT539
KCNC2------------------------------>-<----------------LSPPERLPIRRSST565
KCNC3---------------------------A-->-<----------------MSPEDKSPIT-PGS697
KCNC4---------------------------LAS>S<----------------PTPEERRALRRSTT579
KCND1---------------------------RST>S<----------------VSSQPVGPGSLLSS531
KCND2---------------------------HSP>S<----------------LSSQQ----GVTST528
KCND3---------------------------RSP>S<----------------LSSHP----GLTTT545
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.T495Ac.1483A>G Putative BenignSIFT: tolerated
Polyphen: benign
p.T495Sc.1484C>G Putative BenignSIFT:
Polyphen: