Paralogue Annotation for KCNQ1 residue 65

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 65
Reference Amino Acid: A - Alanine
Protein Domain: N-terminus

Paralogue Variants mapped to KCNQ1 residue 65

No paralogue variants have been mapped to residue 65 for KCNQ1.

KCNQ1	-A--GGALYAPIAPGAPGP--------APP>A<SPAAPAAPPVASDL---GPRPPVSL-----	87
KCNQ2	-------------A-PK------------->-<-RGSILS----------KPRAGG--AGAGK	66
KCNQ3	-----------------DEG-----QR--->R<----TPQ----------GIGL-LAKTPLSR	95
KCNQ4	-----------RRLGLLGSP-----L---->-<-PPGAPLP---------GPGSGSGSACGQR	72
KCNQ5	-----------ATLGGGGGG-----LRESR>R<GKQGARMS---------LLGKPL-SYTSSQ	100
KCNA1	FDPLRNEYFFDRNRPSFDAILYYYQSGGRL>R<RPVNVPLDMFSEEIKFYELGEEAME----K	129
KCNA10	FDSMRNEYFFDRNRPSFDGILYYYQSGGKI>R<RPANVPIDIFADEISFYELGSEAMD----Q	178
KCNA2	FDPLRNEYFFDRNRPSFDAILYYYQSGGRL>R<RPVNVPLDIFSEEIRFYELGEEAME----M	125
KCNA3	FDPLRNEYFFDRNRPSFDAILYYYQSGGRI>R<RPVNVPIDIFSEEIRFYQLGEEAME----K	196
KCNA4	FDPLRNEYFFDRNRPSFDAILYYYQSGGRL>K<RPVNVPFDIFTEEVKFYQLGEEALL----K	268
KCNA5	FDPLRNEYFFDRNRPSFDGILYYYQSGGRL>R<RPVNVSLDVFADEIRFYQLGDEAME----R	212
KCNA6	FDPLRNEYFFDRNRPSFDAILYYYQSGGRL>R<RPVNVPLDIFLEEIRFYQLGDEALA----A	133
KCNA7	YDDARREYFFDRHRPSFDAVLYYYQSGGRL>R<RPAHVPLDVFLEEVAFYGLGAAALA----R	105
KCNB1	YSLDDNEYFFDRHPGAFTSILNFYRT-GRL>H<MMEEMCALSFSQELDYWGIDEIYLE----S	131
KCNB2	YNLNENEYFFDRHPGAFTSILNFYRT-GKL>H<MMEEMCALSFGQELDYWGIDEIYLE----S	135
KCNC1	YDPRADEFFFDRHPGVFAHILNYYRT-GKL>H<CPADVCGPLYEEELAFWGIDETDVE----P	103
KCNC2	HPGGGREFFFDRHPGVFAYVLNYYRT-GKL>H<CPADVCGPLFEEELAFWGIDETDVE----P	150
KCNC3	YDPGADEFFFDRHPGVFAYVLNYYRT-GKL>H<CPADVCGPLFEEELGFWGIDETDVE----A	183
KCNC4	SGGGGCEFFFDRHPGVFAYVLNYYRT-GKL>H<CPADVCGPLFEEELTFWGIDETDVE----P	142
KCND1	YDADSGEYFFDRDPDMFRHVLNFYRT-GRL>H<CPRQECIQAFDEELAFYGLVPELVG----D	130
KCND2	YHPETQQYFFDRDPDIFRHILNFYRT-GKL>H<YPRHECISAYDEELAFFGLIPEIIG----D	131
KCND3	FNEDTKEYFFDRDPEVFRCVLNFYRT-GKL>H<YPRYECISAYDDELAFYGILPEIIG----D	130
KCNF1	YDPGKREFYFDRDPDAFKCVIEVYYF-GEV>H<MKKGICPICFKNEMDFWKVDLKFLD----D	125
KCNG1	YDVTCNEFFFDRNPGAFGTILTFLRA-GKL>R<LLREMCALSFQEELLYWGIAEDHLD----G	163
KCNG2	YDVSRDEFFFDRSPCAFRAIVALLRA-GKL>R<LLRGPCALAFRDELAYWGIDEARLE----R	117
KCNG3	YDRERNEYFFDRHSEAFGFILLYVRGHGKL>R<FAPRMCELSFYNEMIYWGLEGAHLE----Y	110
KCNG4	YDEDSQEFFFDRSPSAFGVIVSFLAA-GKL>V<LLQEMCALSFQEELAYWGIEEAHLE----R	159
KCNS1	YDEAAREFYFDRHPGFFLSLLHFYRT-GHL>H<VLDELCVFAFGQEADYWGLGENALA----A	150
KCNS2	YDDVQREFYFDRNPELFPYVLHFYHT-GKL>H<VMAELCVFSFSQEIEYWGINEFFID----S	117
KCNS3	YSVADKEYYFDRNPSLFRYVLNFYYT-GKL>H<VMEELCVFSFCQEIEYWGINELFID----S	115
KCNV1	ANPVDNEYFFDRSSQAFRYVLHYYRT-GRL>H<VMEQLCALSFLQEIQYWGIDELSID----S	149
KCNV2	YEEQTDEYFFDRDPAVFQLVYNFYLS-GVL>L<VLDGLCPRRFLEELGYWGVRLKYTP----R	197
cons	> <

See full Alignment of Paralogues

Known Variants in KCNQ1

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.A65V	c.194C>T	Putative Benign		rs2522019	SIFT: tolerated Polyphen: benign