Paralogue Annotation for KCNQ1 residue 674

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 674
Reference Amino Acid: E - Glutamate
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 674

No paralogue variants have been mapped to residue 674 for KCNQ1.



KCNQ1-PELFLPS----NTLPTYEQLTVPRRGP-D>E<GS----------------------------676
KCNQ2DHEELERSFSGFSISQSKENLDALNSCY-A>A<VAPCAK---------VRPYIAEGES---DT841
KCNQ3NHEELERSPSGFSISQDRDDYVFGPNGG-S>S<---WMR---------EKRYLAEGET---DT840
KCNQ4------------------------------>-<------------------------------
KCNQ5VPKDLGKSLSVQNLIRSTEELNIQLSGS-E>S<SGSRGSQDFYPKWRESKLFITDEEVGPEET881
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1G--TRSEKNHFESSPLPTSPKFLRQNCIYS>T<EAL-TGKGPSGQEKC-----KL--------833
KCNB2GRDPLREEGSVGSSSPQDTGHNCRQDI-YH>A<VSE-VKKD-SSQEGC-----KM--------885
KCNC1------------------------PTEA-V>R<V-----------------------------584
KCNC2------------------------PVTS-P>Y<NSP---------------------------624
KCNC3------------------------ANAA-A>W<IS----------------------------756
KCNC4------------------------PTAG-T>L<FLP---------------------------634
KCND1PSSPGGGGRAGSTLRNSSLGTPCLFPET-V>K<ISS---------------------------646
KCND2-----GDDRPE--SP------EYSGGNI-V>R<VSA---------------------------629
KCND3-----GESRPPPASPGPNTNIPSIASNV-V>K<VSA---------------------------654
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.E674Kc.2020G>A Putative BenignSIFT: deleterious
Polyphen: benign