Paralogue Annotation for RYR1 residue 421

Residue details

Gene: RYR1
Reference Sequences: Ensembl variant: ENST00000359596 / ENSP00000352608
Amino Acid Position: 421
Reference Amino Acid: S - Serine
Protein Domain:


Paralogue Variants mapped to RYR1 residue 421

No paralogue variants have been mapped to residue 421 for RYR1.



RYR1RCQQEESQAARMIHSTNGLYNQFIKSLDSF>S<GKPRGSGPPAGTALPIEGVILSLQDLIIYF451
RYR2RSQHEESRTARVIRSTVFLFNRFIRGLDAL>S<KKAKA----STVDLPIESVSLSLQDLIGYF463
RYR3RCQREESQAARIIRNTTALFSQFVSGN--->-<-NRTA----APITLPIEEVLQTLQDLIAYF450
cons                              > <                              

See full Alignment of Paralogues


Known Variants in RYR1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.S421Rc.1263C>A Putative BenignSIFT:
Polyphen: