Paralogue Annotation for RYR1 residue 4535

Residue details

Gene: RYR1
Reference Sequences: Ensembl variant: ENST00000359596 / ENSP00000352608
Amino Acid Position: 4535
Reference Amino Acid: E - Glutamate
Protein Domain:


Paralogue Variants mapped to RYR1 residue 4535

No paralogue variants have been mapped to residue 4535 for RYR1.



RYR1VPEPTPEPPKKQ---------APPSPPPKK>E<EAGGEFWGELEVQRVKFLNYLSRNFYTLRF4565
RYR2KAKEDKGKQKLR--------QLHTHRYGEP>E<VPESAFWKKIIAYQQKLLNYFARNFYNMRM4504
RYR3KDKEEEQAEYLWTEVTKKKKRRCGQKVEKP>E<AFTANFFKGLEIYQTKLLHYLARNFYNLRF4415
cons                              > <                              

See full Alignment of Paralogues


Known Variants in RYR1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.E4535Kc.13603G>A Putative Benignrs141444745SIFT:
Polyphen: