Paralogue Annotation for RYR2 residue 1421

Residue details

Gene: RYR2
Reference Sequences: LRG: LRG_402, Ensembl variant: ENST00000366574 / ENSP00000355533
Amino Acid Position: 1421
Reference Amino Acid: M - Methionine
Protein Domain: Cytoplasmic region

Paralogue Variants mapped to RYR2 residue 1421

No paralogue variants have been mapped to residue 1421 for RYR2.

RYR2	RRTKPDYSTSHSARLTEDVLADDRDDYDFL>M<QT-STYYYSVRIFPGQEPANVWVGWITSDF	1450
RYR1	AMMTQPPATPTLPRLPHDVVPADNRDDPEI>I<LNTTTYYYSVRVFAGQEPSCVWAGWVTPDY	1456
RYR3	-----------SPCLDSEAFQKRKQMQEIL>S<HTTTQCYYAIRIFAGQDPSCVWVGWVTPDY	1352
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See full Alignment of Paralogues

Known Variants in RYR2

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.M1421V	c.4261A>G	Putative Benign			SIFT: Polyphen:
p.M1421I	c.4263G>A	Putative Benign			SIFT: Polyphen: