Paralogue Annotation for RYR2 residue 4221

Residue details

Gene: RYR2
Reference Sequences: LRG: LRG_402, Ensembl variant: ENST00000366574 / ENSP00000355533
Amino Acid Position: 4221
Reference Amino Acid: S - Serine
Protein Domain: Cytoplasmic region


Paralogue Variants mapped to RYR2 residue 4221

No paralogue variants have been mapped to residue 4221 for RYR2.



RYR2NFCEDTIFEMQLAAQISESDLNERSANKEE>S<EK-----ERPEEQGPRMAFFSILTVRSALF4246
RYR1SFCEDTIFEMQIAAQISEPEGEPETDEDEG>A<GAAEAGAEGAEEGAAGLEGTAATAAAGATA4295
RYR3NFCEDTIFEMQLASQISESDSADRPEEEEE>D<EDSSYVLEIAGEEEEDGSLEPASAFAMACA4147
cons                              > <                              

See full Alignment of Paralogues


Known Variants in RYR2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.S4221Gc.12661A>G Putative BenignSIFT:
Polyphen:
p.S4221Rc.12663C>G Putative BenignSIFT:
Polyphen: