Paralogue Annotation for SCN5A residue 1642

Residue details

Gene: SCN5A
Reference Sequences: LRG: LRG_289, Ensembl variant: ENST00000333535 / ENSP00000328968
Amino Acid Position: 1642
Reference Amino Acid: G - Glycine
Protein Domain: TM Domain 4


Paralogue Variants mapped to SCN5A residue 1642

No paralogue variants have been mapped to residue 1642 for SCN5A.



SCN5A--KYFFSPTLFRVIRLARIGRILRLIRGAK>G<IRTLLFALMMSLPALFNIGLLLFLVMFIYS1672
SCN1A--KYFVSPTLFRVIRLARIGRILRLIKGAK>G<IRTLLFALMMSLPALFNIGLLLFLVMFIYA1685
SCN2A--KYFVSPTLFRVIRLARIGRILRLIKGAK>G<IRTLLFALMMSLPALFNIGLLLFLVMFIYA1675
SCN3A--KYFVSPTLFRVIRLARIGRILRLIKGAK>G<IRTLLFALMMSLPALFNIGLLLFLVMFIYA1670
SCN4A--KYFVSPTLFRVIRLARIGRVLRLIRGAK>G<IRTLLFALMMSLPALFNIGLLLFLVMFIYS1497
SCN7A--SYLVPPSLVQLILLSRIIHMLRLGKGPK>V<FHNLMLPLMLSLPALLNIILLIFLVMFIYA1395
SCN8A--KYFVSPTLFRVIRLARIGRILRLIKGAK>G<IRTLLFALMMSLPALFNIGLLLFLVMFIFS1666
SCN9A--TYFVSPTLFRVIRLARIGRILRLVKGAK>G<IRTLLFALMMSLPALFNIGLLLFLVMFIYA1648
SCN10A-LQSYFSPTLFRVIRLARIGRILRLIRAAK>G<IRTLLFALMMSLPALFNIGLLLFLVMFIYS1622
SCN11A-EHIPFPPTLFRIVRLARIGRILRLVRAAR>G<IRTLLFALMMSLPSLFNIGLLLFLIMFIYA1512
CACNA1A----FINLSFLRLFRA---ARLIKLLRQGY>T<IRILLWTFVQSFKALPYVCLLIAMLFFIYA1707
CACNA1B--NNFINLSFLRLFRA---ARLIKLLRQGY>T<IRILLWTFVQSFKALPYVCLLIAMLFFIYA1615
CACNA1CEENSRISITFFRLFRV---MRLVKLLSRGE>G<IRTLLWTFIKSFQALPYVALLIVMLFFIYA1375
CACNA1DEESNRISITFFRLFRV---MRLVKLLSRGE>G<IRTLLWTFIKSFQALPYVALLIAMLFFIYA1385
CACNA1E-NTSGFNMSFLKLFRA---ARLIKLLRQGY>T<IRILLWTFVQSFKALPYVCLLIAMLFFIYA1622
CACNA1FEDSSRISITFFRLFRV---MRLVKLLSKGE>G<IRTLLWTFIKSFQALPYVALLIAMIFFIYA1342
CACNA1G-ASLPINPTIIRIMRVLRIARVLKLLKMAV>G<MRALLDTVMQALPQVGNLGLLFMLLFFIFA1758
CACNA1H-AALPINPTIIRIMRVLRIARVLKLLKMAT>G<MRALLDTVVQALPQVGNLGLLFMLLFFIYA1764
CACNA1I-AALPINPTIIRIMRVLRIARVLKLLKMAT>G<MRALLDTVVQALPQVGNLGLLFMLLFFIYA1634
CACNA1SDESARISSAFFRLFRV---MRLIKLLSRAE>G<VRTLLWTFIKSFQALPYVALLIVMLFFIYA1282
cons                              > <                              

See full Alignment of Paralogues


Known Variants in SCN5A

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.G1642Ec.4925G>A Inherited ArrhythmiaBrSSIFT: deleterious
Polyphen: probably damaging
ReportsInherited ArrhythmiaBrS An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. Heart Rhythm. 2010 7(1):33-46. 20129283