Paralogue Annotation for SCN5A residue 581

Residue details

Gene: SCN5A
Reference Sequences: LRG: LRG_289, Ensembl variant: ENST00000333535 / ENSP00000328968
Amino Acid Position: 581
Reference Amino Acid: S - Serine
Protein Domain: Interdomain Linker I-II


Paralogue Variants mapped to SCN5A residue 581

No paralogue variants have been mapped to residue 581 for SCN5A.



SCN5AHHTSLLVPWPL--RRT-SA---QGQPSPGT>S<A----P--GHALHGKKNSTV----------595
SCN1ARRDSLFVPRRHGERRN-----------SNL>S<Q----T--SRSSRMLAVFPAN----GKMHS643
SCN2ARRDSLFVPHRHGERRH-----------SNV>S<Q----A--SRASRVLPILPMN----GKMHS646
SCN3ARRDSLFVPHRHGERRN-----------SNV>S<Q----A--SMSSRMVPGLPAN----GKMHS646
SCN4A------------------------------>-<------------------PAH----GK---504
SCN7A------------------------------>-<------------------------------
SCN8ARRDSLFIPIRARERRS------SYSGYSGY>S<Q----G--SRSSRIFPSLRRS----VKRNS641
SCN9ARRGSLFVPHRPQERRS-----------SNI>S<Q----A--SRSP---PMLPVN----GKMHS620
SCN10AHRGSLLLGGGAGQQG------------PLP>R<SPLPQP--SNP------D------------561
SCN11A------------------------------>-<------------------------------
CACNA1A------------------------------>-<------------------------------
CACNA1B------------------------------>-<------------------------------
CACNA1C------------------------------>-<------------------------------
CACNA1D------------------------------>-<------------------------------
CACNA1E------------------------------>-<------------------------------
CACNA1F------------------------------>-<------------------------------
CACNA1GCHLEPVRCQAPP---PRSPSEASG-RTV-->G<S----G--KVYPTVHTSPPPETLKEKALVE609
CACNA1HCHIEGPQERARVAHAAATA-AASL-R-LAT>G<L----GTMN-YPTILPSGVGSGKGSTSPGP632
CACNA1ISPLDATPHTLVQPIPA-------------->-<------------------------------544
CACNA1S------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in SCN5A

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.S581Lc.1742C>T Putative BenignSIFT:
Polyphen: