Paralogue Annotation for SCN5A residue 662

Residue details

Gene: SCN5A
Reference Sequences: LRG: LRG_289, Ensembl variant: ENST00000333535 / ENSP00000328968
Amino Acid Position: 662
Reference Amino Acid: A - Alanine
Protein Domain: Interdomain Linker I-II


Paralogue Variants mapped to SCN5A residue 662

No paralogue variants have been mapped to residue 662 for SCN5A.



SCN5ASEEPGGPQMLTSQAPCVD-GFEEPGARQR->A<-LSAVSVLTSA----L-EELE-ESR-----680
SCN1ATETEMRKRRSSSFHVSMD-FLEDPSQRQR->A<-MSIASILTNT----V-EELE-ESR-----731
SCN2ATETEIRKRRSSSYHVSMD-LLEDPTSRQR->A<-MSIASILTNT----M-EELE-ESR-----722
SCN3ATETEVRKRRLSSYQISME-MLEDSSGRQR->A<-VSIASILTNT----M-EELE-ESR-----723
SCN4A-------------------E---KGAPRQ->S<-SSGDSGISDA----M-EELE-EAH-----541
SCN7AIQIEMKKRSPISTDTSLD-VLEDATLRHK->-<-----------------EELE-KSK-----468
SCN8ATEVEIKKKGPGSLLVSMD-QLASYGRKDR->I<-NSIMSVVTNTL---V-EELE-ESQ-----716
SCN9ANQIH-KKRRCSSYLLSED-MLNDPNLRQR->A<-MSRASILTNT----V-EELE-ESR-----696
SCN10ASAFD---AGQKKTFLSAE-YLDEPFRAQR->A<-MSVVSIITSV----L-EELE-ESE-----628
SCN11A-----KRLSQNLSLDHFD-EHGDPLQRQR->A<-LSAVSILTIT----M-KEQE-KSQ-----540
CACNA1A---------LLNPEEAED-QLA----DIA->S<-VG---------------------------450
CACNA1B---------LIHAEEGED-RFA----DLC->A<-VG---------------------------446
CACNA1C---------SVNTENVAG-G-D----IEGE>N<-CG---------------------------490
CACNA1D---------SVNTENVSG-EGE----NRG->C<-CGSLWCWWR-------RRGA-AKA-----504
CACNA1E---------AMTRDSSDE-HCV----DIS->S<-VG---------------------------439
CACNA1F---------RS-THSTSSHASL----P-A->S<DTGSMTETQG-------DEDE-EEG-----490
CACNA1G---------ADSGACGPD-SCP----YCA->R<-AG-----AG-----EVELADREMP-DSDS690
CACNA1H---------AGTLTCELK-SCP----YCT->R<-AL-----ED-P---EGELSGSESG-DSDG724
CACNA1I---------------DPA-SCP----CCQ->H<-ED-----GR-RPSGLGS---TDSGQEGSG578
CACNA1S---------SLY-EI--------------->-<-----------------------AG-----403
cons                              > <                              

See full Alignment of Paralogues


Known Variants in SCN5A

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.A662Sc.1984G>T Other Cardiac PhenotypeSIFT: tolerated
Polyphen: benign
ReportsOther Cardiac Phenotype Cardiac channelopathy testing in 274 ethnically diverse sudden unexplained deaths. Forensic Sci Int. 2014 237:90-9. doi: 10.1016/j.forsciint.2014.01.014. 24631775