Paralogue Annotation for RYR2 residue 2781

Residue details

Gene: RYR2
Reference Sequences: LRG: LRG_402, Ensembl variant: ENST00000366574 / ENSP00000355533
Amino Acid Position: 2781
Reference Amino Acid: T - Threonine
Protein Domain: Cytoplasmic region

Paralogue Variants mapped to RYR2 residue 2781

No paralogue variants have been mapped to residue 2781 for RYR2.

RYR2	SKVQPLMKPYKLLSEKEKEIYRWPIKESLK>T<MLAWGWRIERTREGDSMALYNRTRRISQTS	2811
RYR1	LKTHPMLRPYKTFSEKDKEIYRWPIKESLK>A<MIAWEWTIEKAREGEEEK--TEKKKTRKIS	2843
RYR3	VKTHPLIRPFKTLTEKEKEIYRWPARESLK>T<MLAVGWTVERTKEGEALVQQRENEKLRSVS	2708
cons	> <

See full Alignment of Paralogues

Known Variants in RYR2

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.T2781I	c.8342C>T	Putative Benign		rs369963696	SIFT: deleterious Polyphen: probably damaging
p.Thr2781Ser	c.8342C>G	Unknown			SIFT: Polyphen: