Paralogue Annotation for RYR2 residue 3455

Residue details

Gene: RYR2
Reference Sequences: LRG: LRG_402, Ensembl variant: ENST00000366574 / ENSP00000355533
Amino Acid Position: 3455
Reference Amino Acid: K - Lysine
Protein Domain: Cytoplasmic region

Paralogue Variants mapped to RYR2 residue 3455

No paralogue variants have been mapped to residue 3455 for RYR2.

RYR2	FLITDTKSKMSKAA-----VSDQERKKMKR>K<GDRYSMQTSLIVAALKRLLPIGLNICAPGD	3485
RYR1	FLTADNKSKMAKAGDIQSGGSDQERTKKKR>R<GDRYSVQTSLIVATLKKMLPIGLNMCAPTD	3529
RYR3	FLTGDSKSKMSKAMQVKSGGQDQERKKTKR>R<GDLYSIQTSLIVAALKKMLPIGLNMCTPGD	3386
cons	> <

See full Alignment of Paralogues

Known Variants in RYR2

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.K3455R	c.10364A>G	Putative Benign			SIFT: tolerated Polyphen: benign