Paralogue Annotation for RYR2 residue 3461

Residue details

Gene: RYR2
Reference Sequences: LRG: LRG_402, Ensembl variant: ENST00000366574 / ENSP00000355533
Amino Acid Position: 3461
Reference Amino Acid: M - Methionine
Protein Domain: Cytoplasmic region


Paralogue Variants mapped to RYR2 residue 3461

No paralogue variants have been mapped to residue 3461 for RYR2.



RYR2KSKMSKAA-----VSDQERKKMKRKGDRYS>M<QTSLIVAALKRLLPIGLNICAPGDQELIAL3491
RYR1KSKMAKAGDIQSGGSDQERTKKKRRGDRYS>V<QTSLIVATLKKMLPIGLNMCAPTDQDLITL3535
RYR3KSKMSKAMQVKSGGQDQERKKTKRRGDLYS>I<QTSLIVAALKKMLPIGLNMCTPGDQELISL3392
cons                              > <                              

See full Alignment of Paralogues


Known Variants in RYR2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.M3461Vc.10381A>G Putative Benignrs147512481SIFT: tolerated
Polyphen: benign