Paralogue Annotation for RYR2 residue 858

Residue details

Gene: RYR2
Reference Sequences: LRG: LRG_402, Ensembl variant: ENST00000366574 / ENSP00000355533
Amino Acid Position: 858
Reference Amino Acid: T - Threonine
Protein Domain: Cytoplasmic region

Paralogue Variants mapped to RYR2 residue 858

No paralogue variants have been mapped to residue 858 for RYR2.

RYR2	PKEKLKVEHSREYKQERTYTRDLLGPTVSL>T<QAAFTPIPVDTSQIVLPPHLERIREKLAEN	888
RYR1	PRERLHLEPIKEYRREGPRGPHLVGPSRCL>S<HTDFVPCPVDTVQIVLPPHLERIREKLAEN	876
RYR3	PKEKMRLEPVKEYKRDADGIRDLLGTTQFL>S<QASFIPCPVDTSQVILPPHLEKIRDRLAEN	875
cons	> <

See full Alignment of Paralogues

Known Variants in RYR2

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.T858M	c.2573C>T	Putative Benign		rs377068202	SIFT: deleterious Polyphen: possibly damaging