Paralogue Annotation for RYR2 residue 877

Residue details

Gene: RYR2
Reference Sequences: LRG: LRG_402, Ensembl variant: ENST00000366574 / ENSP00000355533
Amino Acid Position: 877
Reference Amino Acid: H - Histidine
Protein Domain: Cytoplasmic region

Paralogue Variants mapped to RYR2 residue 877

No paralogue variants have been mapped to residue 877 for RYR2.

RYR2	TRDLLGPTVSLTQAAFTPIPVDTSQIVLPP>H<LERIREKLAENIHELWVMNKIELGWQYGPV	907
RYR1	GPHLVGPSRCLSHTDFVPCPVDTVQIVLPP>H<LERIREKLAENIHELWALTRIEQGWTYGPV	895
RYR3	IRDLLGTTQFLSQASFIPCPVDTSQVILPP>H<LEKIRDRLAENIHELWGMNKIELGWTFGKI	894
cons	> <

See full Alignment of Paralogues

Known Variants in RYR2

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.H877Y	c.2629C>T	Putative Benign		rs372575878	SIFT: tolerated Polyphen: possibly damaging
p.H877P	c.2630A>C	Putative Benign			SIFT: deleterious Polyphen: probably damaging