Paralogue Annotation for KCNH2 residue 1098

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1098
Reference Amino Acid: S - Serine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1098

No paralogue variants have been mapped to residue 1098 for KCNH2.



KCNH2------------GPGPTSTSPLL-----PV>S<PLP-TLTLDSLSQVSQFMACEELPPGAPEL1127
KCNH1------YPIPEQTLQATVLEVRH-----EL>K<EDIKALNAKMTNIEKQLSEILRILTSRRS-963
KCNH3-----CPRAS-----GEGPCPASTSGLLQP>L<CVDTGASSYCLQPPAGSVLSGTWPHPRPGP968
KCNH4------GHPAGSAWTPDPPCPQL-----RP>-<----PCLSPCASRPPPSLQDTTLAEVH-CP959
KCNH5------YPIPEQALQTTLQEVKH-----EL>K<EDIQLLSCRMTALEKQVAEILKILSEKSVP948
KCNH6------------KTLAPSSEQEQ-----PE>G<LWP-PLASPLHPLEVQGLICG---------960
KCNH7------PIIQLMRTSQPEASIKT-----DR>S<FSPSSQCPEFLDLEKSKLKSKESLSSGVHL1132
KCNH8VCPSRESLQTRTSWSAHQPCLHL-----QT>G<GAAYTQAQLCSSNITSDIWSVDPSSVGSSP970
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1-----------LGRPEGEEEGPA-----EP>E<EHSVRIC-----------------------1226
CNGB3-----------VRR----TVLPR-----GT>S<RQSLIIS-----------------------787
HCN1---------AG----G---RST-------->-<-----VP-QRVTLFRQMSSGAIP------P852
HCN2---------------S---ST--------->-<---PRLG-P-----------------TP-A853
HCN3---------------G---SE--------->-<---R-LP-PSGLL-------AKP------P749
HCN4---------------S---GGLG-----PP>G<RPYGAIPGQHVTLPRKTSSGSLPPPLSLFG1169
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.S1098Rc.3292A>C Putative BenignSIFT: tolerated
Polyphen: benign