Paralogue Annotation for KCNH2 residue 1123

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1123
Reference Amino Acid: G - Glycine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1123

No paralogue variants have been mapped to residue 1123 for KCNH2.



KCNH2--PVSPLP-TLTLDSLSQVSQFMACEELPP>G<APELPQ------------------------1129
KCNH1--ELKEDIKALNAKMTNIEKQLSEILRILT>S<RRS---------------------------963
KCNH3LLQPLCVDTGASSYCLQPPAGSVLSGTWPH>P<RPGPPPL--MAPWPWG-------PPASQSS985
KCNH4--RP-----PCLSPCASRPPPSLQDTTLAE>V<H-CPASV--GTMETG--------TALLDLR975
KCNH5--ELKEDIQLLSCRMTALEKQVAEILKILS>E<KSVPQ-------------------------949
KCNH6--PEGLWP-PLASPLHPLEVQGLICG---->-<------------------------------960
KCNH7--DRSFSPSSQCPEFLDLEKSKLKSKESLS>S<GVHLNTA--SEDNLTSL-------------1143
KCNH8--QTGGAAYTQAQLCSSNITSDIWSVDPSS>V<GSSPQRT--GAHEQNPADSELYHSPSLDYS994
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1--EPEEHSVRIC------------------>-<------------------------------1226
CNGB3--GTSRQSLIIS------------------>-<------------------------------787
HCN1----------VP-QRVTLFRQMSSGAIP-->-<---PNRGVPPAPP-----------------861
HCN2--------PRLG-P---------------->-<TP-AARAAAPSPD-----------------862
HCN3--------R-LP-PSGLL-------AKP-->-<---PRTAQPPRPP-----------------758
HCN4--PPGRPYGAIPGQHVTLPRKTSSGSLPPP>L<SLFGARATSSGGP-----------------1178
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.G1123Rc.3367G>A Putative BenignSIFT:
Polyphen: