Paralogue Annotation for KCNH2 residue 1126

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1126
Reference Amino Acid: E - Glutamate
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1126

No paralogue variants have been mapped to residue 1126 for KCNH2.



KCNH2VSPLP-TLTLDSLSQVSQFMACEELPPGAP>E<LPQ---------------------------1129
KCNH1LKEDIKALNAKMTNIEKQLSEILRILTSRR>S<------------------------------963
KCNH3PLCVDTGASSYCLQPPAGSVLSGTWPHPRP>G<PPPL--MAPWPWG-------PPASQSSP--986
KCNH4P-----PCLSPCASRPPPSLQDTTLAEVH->C<PASV--GTMETG--------TALLDLRP--976
KCNH5LKEDIQLLSCRMTALEKQVAEILKILSEKS>V<PQ----------------------------949
KCNH6EGLWP-PLASPLHPLEVQGLICG------->-<------------------------------960
KCNH7RSFSPSSQCPEFLDLEKSKLKSKESLSSGV>H<LNTA--SEDNLTSL----------------1143
KCNH8TGGAAYTQAQLCSSNITSDIWSVDPSSVGS>S<PQRT--GAHEQNPADSELYHSPSLDYSPSH997
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1PEEHSVRIC--------------------->-<------------------------------1226
CNGB3TSRQSLIIS--------------------->-<------------------------------787
HCN1-------VP-QRVTLFRQMSSGAIP----->-<PNRGVPPAPP--------------------861
HCN2-----PRLG-P-----------------TP>-<AARAAAPSPD--------------------862
HCN3-----R-LP-PSGLL-------AKP----->-<PRTAQPPRPP--------------------758
HCN4PGRPYGAIPGQHVTLPRKTSSGSLPPPLSL>F<GARATSSGGP--------------------1178
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.E1126Kc.3376G>A Putative BenignSIFT: tolerated
Polyphen: probably damaging