Paralogue Annotation for KCNH2 residue 175

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 175
Reference Amino Acid: A - Alanine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 175

No paralogue variants have been mapped to residue 175 for KCNH2.



KCNH2TNHRGPPTSWLAPGRAKTFRLKLPALLALT>A<RESSVRSGGAGGAGAPGAVVVDVDLTPAAP205
KCNH1---------------CKGWG---------->-<------------------------------149
KCNH3---------------WKETGGGRR------>-<------------------------------153
KCNH4---------------GRGDSNHEN------>-<------------------------------154
KCNH5---------------TKGWT---------->-<------------------------------147
KCNH6----------LAKCSSRSLSQRLLSQSFLG>S<EGSHGRPGGPG-------------------167
KCNH7-N----PILPIKTVNRKFFGFKFPGLRVLT>Y<RKQSLPQEDPD------VVVIDS----SKH190
KCNH8------------------DKKEDK------>-<------------------------------149
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1SQVGVGQSEEDGTRPQSTSDQKLWEEVGEE>A<KKEAEEKAKEEAEEVAEEEAEKEPQDWAET443
CNGB3-----SRRNEEGSHPSNQSQQ----TTAQE>E<NKGEEKSLKTKSTPVTSEEPHTNIQDKLSK75
HCN1---------------PAGG---F------->-<------------------------------81
HCN2---------------EAGSEEAG------->-<------------------------------150
HCN3----------------------G------->-<------------------------------41
HCN4----------------AAGDQIL------->-<------------------------------201
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.A175Dc.524C>A Putative BenignSIFT:
Polyphen: