Paralogue Annotation for KCNH2 residue 253

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 253
Reference Amino Acid: A - Alanine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 253

No paralogue variants have been mapped to residue 253 for KCNH2.



KCNH2-----------P--PRSA--PGQLPS--PR>A<HSLNPDASGSS------CSL----ARTRSR273
KCNH1------------------------------>-<------------------------------
KCNH3------------------------------>-<------------------RY----GRAR--159
KCNH4------------------------------>-<------------------SL----GRRG--160
KCNH5------------------------------>-<------------------------------
KCNH6------------------------------>-<------------------------------
KCNH7-----------CSPLVNISGPLDHSSPKRQ>W<DRLYPDMLQSS------SQL----SHSRSR264
KCNH8------------------------------>-<------------------VK----GRSR--155
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1NPPSTVLPPPSPA---KS------------>-<-----DTLIVPSSASGTHRKKLPSEDDEA-522
CNGB3------------------------------>-<---------VP-------------------99
HCN1------------------------------>-<------------------------------
HCN2------------------------------>-<------------------------------
HCN3------------------------------>-<------------------------------
HCN4------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.Ala253Glyc.758C>G UnknownSIFT:
Polyphen: