Paralogue Annotation for KCNH2 residue 260

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 260
Reference Amino Acid: A - Alanine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 260

No paralogue variants have been mapped to residue 260 for KCNH2.



KCNH2----P--PRSA--PGQLPS--PRAHSLNPD>A<SGSS------CSL----ARTRSRESCASVR280
KCNH1------------------------------>-<------------------------------
KCNH3------------------------------>-<-----------RY----GRAR---------159
KCNH4------------------------------>-<-----------SL----GRRG---------160
KCNH5------------------------------>-<------------------------------
KCNH6------------------------------>-<------------------------------
KCNH7----CSPLVNISGPLDHSSPKRQWDRLYPD>M<LQSS------SQL----SHSRSRESLCSIR271
KCNH8------------------------------>-<-----------VK----GRSR---------155
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1PPPSPA---KS------------------D>T<LIVPSSASGTHRKKLPSEDDEA-E------523
CNGB3------------------------------>-<--VP--------------------------99
HCN1------------------------------>-<------------------------------
HCN2------------------------------>-<------------------------------
HCN3------------------------------>-<------------------------------
HCN4------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.A260Vc.779C>T Putative BenignSIFT: tolerated
Polyphen: benign