Paralogue Annotation for KCNH2 residue 280

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 280
Reference Amino Acid: R - Arginine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 280

No paralogue variants have been mapped to residue 280 for KCNH2.



KCNH2ASGSS------CSL----ARTRSRESCASV>R<RASSADDIEAM--------RAGVLPPPPRH302
KCNH1------------------------------>-<------------------------------
KCNH3------------RY----GRAR-------->-<------------------------------159
KCNH4------------SL----GRRG-------->-<------------------------------160
KCNH5------------------------------>-<------------------------------
KCNH6------------------------------>-<------------------------------
KCNH7MLQSS------SQL----SHSRSRESLCSI>R<RASSVHDIEGFGVHPKNIFRDRHASEDNGR301
KCNH8------------VK----GRSR-------->-<------------------------------155
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1TLIVPSSASGTHRKKLPSEDDEA-E----->-<---ELKALSPAESPVVAWSDPTTPKDTDGQ550
CNGB3---VP------------------------->-<---EQKEMDPGKE------GPNSPQNK---117
HCN1------------------------------>-<------------------------------
HCN2------------------------------>-<------------------------------
HCN3------------------------------>-<------------------------------
HCN4------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.R280Cc.838C>T Putative BenignSIFT:
Polyphen: