Paralogue Annotation for KCNH2 residue 40

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 40
Reference Amino Acid: A - Alanine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 40

No paralogue variants have been mapped to residue 40 for KCNH2.



KCNH2EGQSRK-----------FIIANA-RVEN-C>A<VI-YCNDGFCELCGYSRAEVMQRPCTCDFL69
KCNH1--NDTN-----------FVLGNA-QIVD-W>P<IV-YSNDGFCKLSGYHRAEVMQKSSTCSFM70
KCNH3DGTHSN-----------FVLGNA-QVAGLF>P<VV-YCSDGFCDLTGFSRAEVMQRGCACSFL70
KCNH4DGTHSN-----------FLLANA-QGTRGF>P<IV-YCSDGFCELTGYGRTEVMQKTCSCRFL70
KCNH5--SESS-----------FLLGNA-QIVD-W>P<VV-YSNDGFCKLSGYHRADVMQKSSTCSFM68
KCNH6EGQSRK-----------FLIANA-QMEN-C>A<II-YCNDGFCELFGYSRVEVMQQPCTCDFL69
KCNH7EGQNKK-----------FIIANA-RVQN-C>A<II-YCNDGFCEMTGFSRPDVMQKPCTCDFL69
KCNH8DGTHSN-----------FILANA-QVAKGF>P<IV-YCSDGFCELAGFARTEVMQKSCSCKFL70
CNGA1EKE------------I-------------->-<-R-RMEN-----------------------36
CNGA2------------------------------>-<----NHNHHA------PPA-----------23
CNGA3TH-------------L-------------->-<-KVKTSD-----------------------22
CNGA4------------------------------>-<------------------------------
CNGB1QGAEISEMNSPSRRVLTWLMKGVEKVIP-Q>P<VH-SITE----------------DPAQILG130
CNGB3------------------------------>-<------------------------------
HCN1KPNS-------------------------->-<------------------------------9
HCN2RPGE-------------------------->-<------------------------------12
HCN3RPAA-------------------------->-<------------------------------9
HCN4MDEE-------------------------->-<-----EDAEEEG-AGGRQDPSRRSIRLRPL53
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.Ala40Valc.119C>T UnknownSIFT:
Polyphen: