No paralogue variants have been mapped to residue 435 for KCNH2.
| KCNH2 | FKA-VWDWLILLLVIYTAVFTPYSAAFLLK>E<TEEGPPATECGYACQPLAVVDLIVDIMFIV | 465 |
| KCNH1 | FKT-TWDWIILILTFYTAILVPYNVSFKTR>Q<N------------NVAWLVVDSIVDVIFLV | 263 |
| KCNH3 | LRA-TWDGFILLATLYVAVTVPYSVCVSTA>R<E--------PSAARGPPSVCDLAVEVLFIL | 274 |
| KCNH4 | SKA-IWDGLILLATFYVAVTVPYNVCFSGD>D<D--------TPITSRHTLVSDIAVEMLFIL | 276 |
| KCNH5 | FKT-TWDWVILILTFYTAIMVPYNVSFKTK>Q<N------------NIAWLVLDSVVDVIFLV | 260 |
| KCNH6 | FKA-VWDWLILLLVIYTAVFTPYSAAFLLS>D<QDE-SRRGACSYTCSPLTVVDLIVDIMFVV | 313 |
| KCNH7 | FKA-VWDWLILLLVIYTAIFTPYSAAFLLN>D<REE-QKRRECGYSCSPLNVVDLIVDIMFII | 464 |
| KCNH8 | FKA-GWDWLILLATFYVAVTVPYNVCFIGN>D<D--------LS-TTRSTTVSDIAVEILFII | 270 |
| CNGA1 | TYY-NWLFCITLPVMYNWTMVIARACFDEL>Q<S----------DYLEYWLILDYVSDIVYLI | 213 |
| CNGA2 | WYY-CWLFVIAMPVLYNWCLLVARACFSDL>Q<K----------GYYLVWLVLDYVSDVVYIA | 188 |
| CNGA3 | LYY-RWLTAIALPVFYNWYLLICRACFDEL>Q<S----------EYLMLWLVLDYSADVLYVL | 216 |
| CNGA4 | YYY-WWLNTMVFPVMYNLIILVCRACFPDL>Q<H----------GYLVAWLVLDYTSDLLYLL | 82 |
| CNGB1 | LMYVLWLFFVVMAWNWNCWLIPVRWAFPYQ>T<P----------DNIHHWLLMDYLCDLIYFL | 704 |
| CNGB3 | RLYLLWLLLVTLAYNWNCCFIPLRLVFPYQ>T<A----------DNIHYWLIADIICDIIYLY | 266 |
| HCN1 | FRF-YWDLIMLIMMVGNLVIIPVGITFFTE>Q<T------------TTPWIIFNVASDTVFLL | 188 |
| HCN2 | FRF-YWDFTMLLFMVGNLIIIPVGITFFKD>E<T------------TAPWIVFNVVSDTFFLM | 257 |
| HCN3 | FRF-YWDLIMLLLMVGNLIVLPVGITFFKE>E<N------------SPPWIVFNVLSDTFFLL | 139 |
| HCN4 | FRF-YWDLTMLLLMVGNLIIIPVGITFFKD>E<N------------TTPWIVFNVVSDTFFLI | 308 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.E435G | c.1304A>G | Putative Benign | SIFT: Polyphen: |