Paralogue Annotation for KCNH2 residue 972

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 972
Reference Amino Acid: P - Proline
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 972

No paralogue variants have been mapped to residue 972 for KCNH2.



KCNH2P---GRSSSPLRLVPFSSP-RPPGEPPGGE>P<LMEDC-------------------------977
KCNH1V---VTVRESPATPVSFQA-ASTSGVPDHA>K<LQAPGS------------------------819
KCNH3L---GGRGRPGRAGALKAE-AGPSAPPRAL>E<G-----------------------------806
KCNH4S---LSPSLSPALAGQGHS-ASPHGPPRCS>A<AWKPPQ------------------------809
KCNH5Q---ITPIQTSLAYVKTSE-SLKQNNRDAM>E<LKPNGG------------------------789
KCNH6G---LWPELLQEMPPRHSP-QSPQEDPDCW>P<LKLGSR------------------------825
KCNH7K---PLFSGIVDSSPGIGK-ASGLDFEETV>P<TSGRMH------------------------978
KCNH8F---HSPIRVSRSNSPKTK-QEIDPPNHNK>R<KEKNLK------------------------795
CNGA1D---S------------------------->-<------------------------------689
CNGA2D---E------------------------->-<------------------------------663
CNGA3K---Q------------------------->-<------------------------------693
CNGA4K---DE------------------------>-<------------------------------562
CNGB1Q-----------HTHPKEA----------->-<------------------------------1179
CNGB3N-----------EDKGKE------------>-<------------------------------736
HCN1NL-H--------S----------------->-<------------------------------680
HCN2LVGP-------------------------->-<------------------------------749
HCN3HQRG--------P----------------->-<------------------------------630
HCN4HHPRLPAAIFRPPPGSGLGNLGAGQTPRHL>K<RLQSLIPSALGSASPASSPSQVDTPSSSSF857
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.P972Lc.2915C>T Putative BenignSIFT: tolerated
Polyphen: possibly damaging