No paralogue variants have been mapped to residue 116 for KCNQ1.
| KCNQ1 | --------------------VQGRVYNFLE>R<PT-GWKCFVYHFAVFLIVLVCLIFSVLSTI | 145 |
| KCNQ2 | --------------------LQNFLYNVLE>R<PR-G-WAFIYHAYVFLLVFSCLVLSVFSTI | 115 |
| KCNQ3 | --------------------IQTLIYDALE>R<PR-G-WALLYHALVFLIVLGCLILAVLTTF | 145 |
| KCNQ4 | --------------------LQNWVYNVLE>R<PR-G-WAFVYHVFIFLLVFSCLVLSVLSTI | 121 |
| KCNQ5 | --------------------VQNYLYNVLE>R<PR-G-WAFIYHAFVFLLVFGCLILSVFSTI | 149 |
| KCNA1 | ---------------P-EKEYQRQVWLLFE>Y<PESSGPARVIAIVSVMVILISIVIFCLETL | 189 |
| KCNA10 | ---------------P-TNDIHRQFWLLFE>Y<PESSSAARAVAVVSVLVVVISITIFCLETL | 238 |
| KCNA2 | ---------------P-ENEFQRQVWLLFE>Y<PESSGPARIIAIVSVMVILISIVSFCLETL | 185 |
| KCNA3 | ---------------P-RRDFQRQVWLLFE>Y<PESSGPARGIAIVSVLVILISIVIFCLETL | 256 |
| KCNA4 | ---------------P-ENEFKKQIWLLFE>Y<PESSSPARGIAIVSVLVILISIVIFCLETL | 329 |
| KCNA5 | ---------------P-RNEFQRQVWLIFE>Y<PESSGSARAIAIVSVLVILISIITFCLETL | 272 |
| KCNA6 | ---------------P-SQPFQRQVWLLFE>Y<PESSGPARGIAIVSVLVILISIVIFCLETL | 196 |
| KCNA7 | ---------------P-RRAFARQLWLLFE>F<PESSQAARVLAVVSVLVILVSIVVFCLETL | 165 |
| KCNB1 | ---F-------DNTC--CAEKRKKLWDLLE>K<PNSSVAAKILAIISIMFIVLSTIALSLNTL | 211 |
| KCNB2 | ---F-------DNTC--CPDKRKKLWDLLE>K<PNSSVAAKILAIVSILFIVLSTIALSLNTL | 215 |
| KCNC1 | -PDG-------RPGGF-WRRWQPRIWALFE>D<PYSSRYARYVAFASLFFILVSITTFCLETH | 212 |
| KCNC2 | GPDG-------KSGR--WRRLQPRMWALFE>D<PYSSRAARFIAFASLFFILVSITTFCLETH | 251 |
| KCNC3 | GAGGPPGGAGGAGGTW-WRRWQPRVWALFE>D<PYSSRAARYVAFASLFFILISITTFCLETH | 312 |
| KCNC4 | GHGA-------GSGG--CRGWQPRMWALFE>D<PYSSRAARVVAFASLFFILVSITTFCLETH | 248 |
| KCND1 | ---------------PAGSSLRQRLWRAFE>N<PHTSTAALVFYYVTGFFIAVSVIANVVETI | 208 |
| KCND2 | ---------------PTMT-ARQRVWRAFE>N<PHTSTMALVFYYVTGFFIAVSVIANVVETV | 207 |
| KCND3 | ---------------PSLS-FRQTMWRAFE>N<PHTSTLALVFYYVTGFFIAVSVITNVVETV | 205 |
| KCNF1 | ---A-------AEGR--WRRCQKCVWKFLE>K<PESSCPARVVAVLSFLLILVSSVVMCMGTI | 204 |
| KCNG1 | ---E-------GEGRL-GR-CMRRLRDMVE>R<PHSGLPGKVFACLSVLFVTVTAVNLSVSTL | 249 |
| KCNG2 | ---G-------PRGRL-QR-GRRRLRDVVD>N<PHSGLAGKLFACVSVSFVAVTAVGLCLSTM | 199 |
| KCNG3 | ---G-------AEAAP-SRRWLERMRRTFE>E<PTSSLAAQILASVSVVFVIVSMVVLCASTL | 193 |
| KCNG4 | ---S-------HSSRW-GL-CMNRLREMVE>N<PQSGLPGKVFACLSILFVATTAVSLCVSTM | 243 |
| KCNS1 | ---Y-------GAAR--CGRLRRRLWLTME>N<PGYSLPSKLFSCVSISVVLASIAAMCIHSL | 242 |
| KCNS2 | ---F-------DGQP--LGNFRRQLWLALD>N<PGYSVLSRVFSILSILVVMGSIITMCLNSL | 209 |
| KCNS3 | ---F-------DTLR--FGQLRKKIWIRME>N<PAYCLSAKLIAISSLSVVLASIVAMCVHSM | 207 |
| KCNV1 | ---F-------SQGP--CPTVRQKLWNILE>K<PGSSTAARIFGVISIIFVVVSIINMALMSA | 232 |
| KCNV2 | ---F-------RDMRF-YGPQRRRLWNLME>K<PFSSVAAKAIGVASSTFVLVSVVALALNTV | 282 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.Arg116His | c.347G>A | Unknown | SIFT: Polyphen: |