Paralogue Annotation for KCNQ1 residue 145

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 145
Reference Amino Acid: I - Isoleucine
Protein Domain: Transmembrane/Linker/Pore

Paralogue Variants mapped to KCNQ1 residue 145

No paralogue variants have been mapped to residue 145 for KCNQ1.

KCNQ1	RPT-GWKCFVYHFAVFLIVLVCLIFSVLST>I<EQYA--------------------------	149
KCNQ2	RPR-G-WAFIYHAYVFLLVFSCLVLSVFST>I<KEYE--------------------------	119
KCNQ3	RPR-G-WALLYHALVFLIVLGCLILAVLTT>F<KEYE--------------------------	149
KCNQ4	RPR-G-WAFVYHVFIFLLVFSCLVLSVLST>I<QEHQ--------------------------	125
KCNQ5	RPR-G-WAFIYHAFVFLLVFGCLILSVFST>I<PEHT--------------------------	153
KCNA1	YPESSGPARVIAIVSVMVILISIVIFCLET>L<PELKDDK-DF--------TG----------	200
KCNA10	YPESSSAARAVAVVSVLVVVISITIFCLET>L<PEFREDR-EL--------KV----------	249
KCNA2	YPESSGPARIIAIVSVMVILISIVSFCLET>L<PIFRDEN-ED--------MHGSG---V---	200
KCNA3	YPESSGPARGIAIVSVLVILISIVIFCLET>L<PEFRDEK-DY--------PA-ST---SQD-	272
KCNA4	YPESSSPARGIAIVSVLVILISIVIFCLET>L<PEFRDDR-DL--------VM-AL---SAG-	345
KCNA5	YPESSGSARAIAIVSVLVILISIITFCLET>L<PEFRDER-ELLRHPPAP---------HQPP	292
KCNA6	YPESSGPARGIAIVSVLVILISIVIFCLET>L<PQFRVDG-RGGNNGGVSRVS-PVSRGSQEE	224
KCNA7	FPESSQAARVLAVVSVLVILVSIVVFCLET>L<PDFRDDR-DGTGL-----AA-AA---AAG-	184
KCNB1	KPNSSVAAKILAIISIMFIVLSTIALSLNT>L<PELQSLD-EF--------GQ----------	222
KCNB2	KPNSSVAAKILAIVSILFIVLSTIALSLNT>L<PELQETD-EF--------GQ----------	226
KCNC1	DPYSSRYARYVAFASLFFILVSITTFCLET>H<ERFNPIV-NK--------TE-I----E---	225
KCNC2	DPYSSRAARFIAFASLFFILVSITTFCLET>H<EAFNI---VK--------NK-T----E---	262
KCNC3	DPYSSRAARYVAFASLFFILISITTFCLET>H<EGFIHIS-NK--------TV-T----QA--	326
KCNC4	DPYSSRAARVVAFASLFFILVSITTFCLET>H<EAFNI---DR-NV-----TE-I----L---	261
KCND1	NPHTSTAALVFYYVTGFFIAVSVIANVVET>I<PCRGSAR-RS--------SR----------	219
KCND2	NPHTSTMALVFYYVTGFFIAVSVIANVVET>V<PCGS-SP-GH--------IK----------	217
KCND3	NPHTSTLALVFYYVTGFFIAVSVITNVVET>V<PCGT-VP-G---------SK----------	214
KCNF1	KPESSCPARVVAVLSFLLILVSSVVMCMGT>I<PELQVLD-AE--------GN----------	215
KCNG1	RPHSGLPGKVFACLSVLFVTVTAVNLSVST>L<PSLREEEE-Q--------GH----------	260
KCNG2	NPHSGLAGKLFACVSVSFVAVTAVGLCLST>M<PDIRAEEE-R--------GE----------	210
KCNG3	EPTSSLAAQILASVSVVFVIVSMVVLCAST>L<PDWRN-AAAD--------NR----------	204
KCNG4	NPQSGLPGKVFACLSILFVATTAVSLCVST>M<PDLRAEED-Q--------GE----------	254
KCNS1	NPGYSLPSKLFSCVSISVVLASIAAMCIHS>L<PEYQARE-AA--------AA----------	253
KCNS2	NPGYSVLSRVFSILSILVVMGSIITMCLNS>L<PDFQIPD-SQ--------GN----------	220
KCNS3	NPAYCLSAKLIAISSLSVVLASIVAMCVHS>M<SEFQNED-GE--------------------	216
KCNV1	KPGSSTAARIFGVISIIFVVVSIINMALMS>A<EL-----------------S----------	235
KCNV2	KPFSSVAAKAIGVASSTFVLVSVVALALNT>V<EEMQQHS-GQ--------GE----------	293
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See full Alignment of Paralogues

Known Variants in KCNQ1

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.I145M	c.435C>G	Putative Benign		rs1800170	SIFT: tolerated Polyphen: probably damaging