Paralogue Annotation for KCNQ1 residue 462

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 462
Reference Amino Acid: D - Aspartate
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 462

No paralogue variants have been mapped to residue 462 for KCNQ1.



KCNQ1VPHITCDPPEERRL--------DHFSVDGY>D<SSVRKSPTLLEV---SM-------------476
KCNQ2AQTVRRSPSADQSLED-SPSKVPKSW--SF>G<DRSRARQAF------RIKG-----------500
KCNQ3-----FTPLNVDAIEE-SPSKEPKPV--GL>N<NKERFRTAF------RMKA-----------480
KCNQ4PPTMPTSPSSEQVGEATSPTKVQKSW--SF>N<DRTRFRASL------RLK------------498
KCNQ5SVGDRRSPSTDITAEG-SPTKVQKSW--SF>N<DRTRFRPSL------RLKS-----------481
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1PEK-------ARSSSSPQH-----L----->-<---------NVQQLEDMYNKMAKTQ--SQP543
KCNB2SQKDSHEQLNNTSSSSPQH-----L----->-<---------SAQKLEMLYNEITKTQPHSHP556
KCNC1------------------------------>-<------------------------------
KCNC2------------------------------>-<------------------------------
KCNC3------------------------------>-<------------------------------
KCNC4------------------------------>-<------------------------------
KCND1-----------F------------T----->-<---------DEL------------------497
KCND2-----------F------------V----->-<---------DEQ------------------497
KCND3-----------F------------I----->-<---------DEQ------------------514
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.D462Nc.1384G>A Putative BenignSIFT:
Polyphen: