Paralogue Annotation for KCNQ1 residue 646

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 646
Reference Amino Acid: G - Glycine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 646

No paralogue variants have been mapped to residue 646 for KCNQ1.



KCNQ1TPGSGGPPREGG--------AHITQPCGSG>G<S-----------------------------647
KCNQ2APPYHSPEDSREH---VDRHGCIVKIVRSS>S<STGQ------------------K----NFS702
KCNQ3TKGTSSPAEAEK--KEDNRYSDLKTIICNY>S<ETGPPEPP-------------------YSF699
KCNQ4TSDYHSPVDHEDISVSAQTL-SISRSVSTN>M<------------------------------694
KCNQ5TSDYQSPVDSKDLSGSAQNSGCLSRSTSAN>I<SRGLQFILTPNEFSAQTFYALSP----TMH710
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1---------------TLLDK---------->-<-------AVLSPESSIYTTASAKTPPRSPE739
KCNB2---------------SQGDR---------->-<-------PLLGTEVSAPCQGPSKGLSPRFP789
KCNC1------------------------------>-<------------------------------
KCNC2------------------------------>-<------------------------------
KCNC3------------------------------>-<------------------------------
KCNC4------------------------------>-<------------------------------
KCND1------------------------------>-<------------------------------
KCND2------------------------------>-<------------------------------
KCND3------------------------------>-<------------------------------
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.G646Sc.1936G>A Putative BenignSIFT:
Polyphen: