Paralogue Annotation for KCNQ1 residue 657

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 657
Reference Amino Acid: N - Asparagine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 657

No paralogue variants have been mapped to residue 657 for KCNQ1.



KCNQ1-------------------PELFLPS---->N<TLPTYEQLTVPRRGP-DEGS----------676
KCNQ2PPEGNLRDSDTSISIPSVDHEELERSFSGF>S<ISQSKENLDALNSCY-AAVAPCAK------829
KCNQ3QRRSITRDSDTPLSLMSVNHEELERSPSGF>S<ISQDRDDYVFGPNGG-SS---WMR------828
KCNQ4------------------------------>-<------------------------------
KCNQ5MRKSFDMGGETLLSVCPMVPKDLGKSLSVQ>N<LIRSTEELNIQLSGS-ESSGSRGSQDFYPK863
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1PPK---SLPGSTSPKFSTG--TRSEKNHFE>S<SPLPTSPKFLRQNCIYSTEAL-TGKGPSGQ828
KCNB2VD----SSPNCFADKPSDGRDPLREEGSVG>S<SSPQDTGHNCRQDI-YHAVSE-VKKD-SSQ880
KCNC1------------------------------>-<-----------PTEA-VRV-----------584
KCNC2------------------------------>-<-----------PVTS-PYNSP---------624
KCNC3------------------------------>-<-----------ANAA-AWIS----------756
KCNC4------------------------------>-<-----------PTAG-TLFLP---------634
KCND1PPA---NT-----PDESQPSSPGGGGRAGS>T<LRNSSLGTPCLFPET-VKISS---------646
KCND2PPV---TT-----PE--------GDDRPE->-<SP------EYSGGNI-VRVSA---------629
KCND3PPA---LT-----PE--------GESRPPP>A<SPGPNTNIPSIASNV-VKVSA---------654
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.N657Sc.1970A>G Putative BenignSIFT: tolerated
Polyphen: benign