Titin Variants in Dilated Cardiomyopathy

TTN Transcript / Exon Structure & Truncating Variants in Cardiomyopathy Studies

TTN Transcript & Exon Structure

Titin Transcripts

Reference identifiers for seven titin transcripts, including the inferred-complete meta-transcript (manually annotated by the Havana Group) that is the recommended transcript for variant reporting. Links are provided to each reference source. The complete exon structure of these transcripts is shown in the Titin Exon table below.

Transcript	Description	Length (aa)	No. exons	Ensembl transcript	Ensembl protein	Refseq transcript	Refseq protein	LRG	Uniprot
Meta	Inferred complete meta-transcript	35991	363	ENST00000589042	ENSP00000467141	NM_001267550.1	NP_001254479	391_t1
N2BA	Principle cardiac long isoform	34350	313	ENST00000591111	ENSP00000465570	NM_001256850.1	NP_001243779		Q8WZ42-1
N2B	Principle cardiac short isoform	26926	191	ENST00000460472	ENSP00000434586	NM_003319.4	NP_003310.4		Q8WZ42-3
N2A	Soleus / skeletal long isoform	33423	312	ENST00000342992	ENSP00000343764	NM_133378.4	NP_596869.4		Q8WZ42-4
Novex-1	Minor cardiac short isoform	27051	192	ENST00000359218	ENSP00000352154	NM_133432.3	NP_597676.3		Q8WZ42-8
Novex-2	Minor cardiac short isoform	27118	192	ENST00000342175	ENSP00000340554	NM_133437.3	NP_597681.3		Q8WZ42-7
Novex-3	Minor small cardiac isoform	5604	46	ENST00000360870	ENSP00000354117	NM_133379.3	NP_596870.2	391_t2	Q8WZ42-6

Titin Exons

This table contains details for each of the 364 exons which comprise the Titin gene, including genomic and meta transcript coordinates, associated titin transcripts, region and domain structure and more. For more details on individual exons, click on a selected row.

Domains:		Ig-like domain		Z-repeat		PEVK domain		Fibronectin type III domain		Protein kinase

Exon1 Number	Hg19 start	Hg19 end	Hg385 start	Hg38 end	Meta start	Meta end	Exon Rank in Transcript							PSI%2	Band	Domains	Coding length	Symmetry / Phase3
Exon1 Number	Hg19 start	Hg19 end	Hg385 start	Hg38 end	Meta start	Meta end	Meta	N2BA	N2B	N2A	Nvx1	Nvx2	Nvx3	PSI%2	Band	Domains	Coding length	Symmetry / Phase3
1	179672150	179671939	178807423	178807212			1	1	1	1	1	1	1	100			0
2	179669382	179669279	178804655	178804552	1	91	2	2	2	2	2	2	2	100	Z-disk		91	A / 1
3	179667068	179666865	178802341	178802138	92	295	3	3	3	3	3	3	3	100	Z-disk		204	S / 1
4	179665409	179665122	178800682	178800395	296	583	4	4	4	4	4	4	4	100	Z-disk		288	S / 1
5	179664637	179664552	178799910	178799825	584	669	5	5	5	5	5	5	5	100	Z-disk		86	A / 0
6	179664458	179664214	178799731	178799487	670	914	6	6	6	6	6	6	6	100	Z-disk		245	A / 2
7	179659979	179659649	178795252	178794922	915	1245	7	7	7	7	7	7	7	100	Z-disk		331	A / 0
8	179659278	179659126	178794551	178794399	1246	1398	8	8	8	8	8	8	8	100	Z-disk		153	S / 0
9	179658268	179658131	178793541	178793404	1399	1536	9	9	9	9	9	9	9	100	Z-disk		138	S / 0
10	179656924	179656799	178792197	178792072	1537	1662	10	10	10	10	10	10	10	100	Z-disk		126	S / 0
11	179655572	179655435	178790845	178790708	1663	1800	11	11		11			11	51	Z-disk		138	S / 0
12	179654842	179654705	178790115	178789978	1801	1938	12	12	11	12	11	11	12	79	Z-disk		138	S / 0
13	179654224	179654087	178789497	178789360	1939	2076	13	13	12	13	12	12	13	96	Z-disk		138	S / 0
14	179650868	179650575	178786141	178785848	2077	2370	14	14	13	14	13	13	14	100	Z-disk		294	S / 0
15	179650469	179650347	178785742	178785620	2371	2493	15	15	14	15	14	14	15	99	Z-disk		123	S / 0
16	179649078	179648797	178784351	178784070	2494	2775	16	16	15	16	15	15	16	99	near Z-disk		282	S / 0
17	179648512	179648447	178783785	178783720	2776	2841	17	17	16	17	16	16	17	99	near Z-disk		66	S / 0
18	179647791	179647533	178783064	178782806	2842	3100	18	18	17	18	17	17	18	100	near Z-disk		259	A / 1
19	179647329	179647266	178782602	178782539	3101	3164	19	19	18	19	18	18	19	100	near Z-disk		64	A / 2
20	179647154	179646939	178782427	178782212	3165	3380	20	20	19	20	19	19	20	100	near Z-disk		216	S / 2
21	179645990	179645848	178781263	178781121	3381	3523	21	21	20	21	20	20	21	100	near Z-disk		143	A / 1
22	179644932	179644727	178780205	178780000	3524	3729	22	22	21	22	21	21	22	100	near Z-disk		206	A / 0
23	179644189	179643956	178779462	178779229	3730	3963	23	23	22	23	22	22	23	100	near Z-disk		234	S / 0
24	179643845	179643601	178779118	178778874	3964	4208	24	24	23	24	23	23	24	100	near Z-disk		245	A / 2
25	179642702	179642431	178777975	178777704	4209	4480	25	25	24	25	24	24	25	100	near Z-disk		272	A / 1
26	179642311	179642147	178777584	178777420	4481	4645	26	26	25	26	25	25	26	100	near Z-disk		165	S / 1
27	179642044	179641876	178777317	178777149	4646	4814	27	27	26	27	26	26	27	100	near Z-disk		169	A / 2
28	179641776	179640083	178777049	178775356	4815	6508	28	28	27	28	27	27	28	100	near Z-disk / I-band		1694	A / 1
29	179639929	179639648	178775202	178774921	6509	6790	29	29	28	29	28	28	29	100	I-band		282	S / 1
30	179639200	179638934	178774473	178774207	6791	7057	30	30	29	30	29	29	30	100	I-band		267	S / 1
31	179638837	179638565	178774110	178773838	7058	7330	31	31	30	31	30	30	31	100	I-band		273	S / 1
32	179638452	179638189	178773725	178773462	7331	7594	32	32	31	32	31	31	32	100	I-band		264	S / 1
33	179638096	179637836	178773369	178773109	7595	7855	33	33	32	33	32	32	33	100	I-band		261	S / 1
34	179636198	179635938	178771471	178771211	7856	8116	34	34	33	34	33	33	34	100	I-band		261	S / 1
35	179635402	179635139	178770675	178770412	8117	8380	35	35	34	35	34	34	35	100	I-band		264	S / 1
36	179635047	179634787	178770320	178770060	8381	8641	36	36	35	36	35	35	36	100	I-band		261	S / 1
37	179634666	179634406	178769939	178769679	8642	8902	37	37	36	37	36	36	37	100	I-band		261	S / 1
38	179633660	179633400	178768933	178768673	8903	9163	38	38	37	38	37	37	38	100	I-band		261	S / 1
39	179632882	179632741	178768155	178768014	9164	9305	39	39	38	39	38	38	39	100	I-band		142	A / 2
40	179632651	179632486	178767924	178767759	9306	9471	40	40	39	40	39	39	40	100	I-band		166	A / 0
41	179631339	179631108	178766612	178766381	9472	9703	41	41	40	41	40	40	41	100	I-band		232	A / 1
42	179629538	179629254	178764811	178764527	9704	9988	42	42	41	42	41	41	42	100	I-band		285	S / 1
43	179629029	179628904	178764302	178764177	9989	10114	43	43	42	43	42	42	43	100	I-band		126	S / 1
44	179623899	179623711	178759172	178758984	10115	10303	44	44	43	44	43	43	44	100	I-band		189	S / 1
45	179622643	179622269	178757916	178757542	10304	10678	45				44			1			375	S / 1
46	179621524	179620949	178756797	178756222	10679	11254	46					44		4			576	S / 1
47	179617907	179617851	178753180	178753124	11255	11311	47	45	44	45	45	45	45	100	I-band		57	S / 1
48	179616766	179610047	178752039	178745320									46	n/a4			6455	A / -
49	179606648	179603868	178741921	178739141	11312	14092	48	46	45		46	46		100	I-band		2781	S / 1
50	179603087	179602809	178738360	178738082	14093	14371	49	47	46	46	47	47		100	I-band		279	S / 1
51	179600801	179600238	178736074	178735511	14372	14935	50	48		47				33	I-band		564	S / 1
52	179599715	179599434	178734988	178734707	14936	15217	51	49		48				15	I-band		282	S / 1
53	179599333	179599055	178734606	178734328	15218	15496	52	50		49				10	I-band		279	S / 1
54	179598619	179598341	178733892	178733614	15497	15775	53	51		50				7	I-band		279	S / 1
55	179598244	179597966	178733517	178733239	15776	16054	54	52		51				6	I-band		279	S / 1
56	179597848	179597561	178733121	178732834	16055	16342	55	53		52				6	I-band		288	S / 1
57	179597445	179597167	178732718	178732440	16343	16621	56	54		53				7	I-band		279	S / 1
58	179597074	179596793	178732347	178732066	16622	16903	57	55		54				7	I-band		282	S / 1
59	179596698	179596420	178731971	178731693	16904	17182	58	56		55				8	I-band		279	S / 1
60	179596310	179596032	178731583	178731305	17183	17461	59	57		56				20	I-band		279	S / 1
61	179595930	179595652	178731203	178730925	17462	17740	60	58		57				35	I-band		279	S / 1
62	179595519	179595232	178730792	178730505	17741	18028	61	59		58				32	I-band		288	S / 1
63	179595098	179594820	178730371	178730093	18029	18307	62	60		59				6	I-band		279	S / 1
64	179594672	179594391	178729945	178729664	18308	18589	63	61		60				7	I-band		282	S / 1
65	179594293	179594015	178729566	178729288	18590	18868	64	62		61				8	I-band		279	S / 1
66	179593896	179593618	178729169	178728891	18869	19147	65	63		62				4	I-band		279	S / 1
67	179593505	179593227	178728778	178728500	19148	19426	66	64		63				7	I-band		279	S / 1
68	179593124	179592837	178728397	178728110	19427	19714	67	65		64				6	I-band		288	S / 1
69	179592590	179592312	178727863	178727585	19715	19993	68	66		65				6	I-band		279	S / 1
70	179592098	179591817	178727371	178727090	19994	20275	69	67		66				52	I-band		282	S / 1
71	179590773	179590495	178726046	178725768	20276	20554	70	68		67				46	I-band		279	S / 1
72	179590376	179590095	178725649	178725368	20555	20836	71	69		68				46	I-band		282	S / 1
73	179589265	179588987	178724538	178724260	20837	21115	72	70		69				26	I-band		279	S / 1
74	179588870	179588583	178724143	178723856	21116	21403	73	71		70				25	I-band		288	S / 1
75	179588423	179588145	178723696	178723418	21404	21682	74	72		71				34	I-band		279	S / 1
76	179588051	179587773	178723324	178723046	21683	21961	75	73		72				32	I-band		279	S / 1
77	179587664	179587386	178722937	178722659	21962	22240	76	74		73				56	I-band		279	S / 1
78	179587273	179586986	178722546	178722259	22241	22528	77	75		74				33	I-band		288	S / 1
79	179586861	179586574	178722134	178721847	22529	22816	78	76		75				35	I-band		288	S / 1
80	179585929	179585648	178721202	178720921	22817	23098	79	77		76				41	I-band		282	S / 1
81	179585390	179585112	178720663	178720385	23099	23377	80	78		77				41	I-band		279	S / 1
82	179584991	179584710	178720264	178719983	23378	23659	81	79		78				46	I-band		282	S / 1
83	179584559	179584281	178719832	178719554	23660	23938	82	80		79				48	I-band		279	S / 1
84	179584178	179583891	178719451	178719164	23939	24226	83	81		80				7	I-band		288	S / 1
85	179583700	179583422	178718973	178718695	24227	24505	84	82		81				3	I-band		279	S / 1
86	179583327	179583049	178718600	178718322	24506	24784	85	83		82				4	I-band		279	S / 1
87	179582948	179582670	178718221	178717943	24785	25063	86	84		83				4	I-band		279	S / 1
88	179582537	179582250	178717810	178717523	25064	25351	87	85		84				4	I-band		288	S / 1
89	179582109	179581822	178717382	178717095	25352	25639	88	86		85				8	I-band		288	S / 1
90	179580501	179580220	178715774	178715493	25640	25921	89	87		86				59	I-band		282	S / 1
91	179579991	179579713	178715264	178714986	25922	26200	90	88		87				54	I-band		279	S / 1
92	179579300	179579019	178714573	178714292	26201	26482	91	89		88				60	I-band		282	S / 1
93	179578902	179578624	178714175	178713897	26483	26761	92	90		89				62	I-band		279	S / 1
94	179578099	179577812	178713372	178713085	26762	27049	93	91		90				60	I-band		288	S / 1
95	179577702	179577424	178712975	178712697	27050	27328	94	92		91				64	I-band		279	S / 1
96	179577320	179577042	178712593	178712315	27329	27607	95	93		92				63	I-band		279	S / 1
97	179576949	179576671	178712222	178711944	27608	27886	96	94		93				61	I-band		279	S / 1
98	179576076	179575789	178711349	178711062	27887	28174	97	95		94				66	I-band		288	S / 1
99	179575649	179575362	178710922	178710635	28175	28462	98	96		95				66	I-band		288	S / 1
100	179574583	179574293	178709856	178709566	28463	28753	99	97		96				69	I-band		291	S / 1
101	179572540	179572253	178707813	178707526	28754	29041	100	98		97				72	I-band		288	S / 1
102	179571681	179571589	178706954	178706862	29042	29134	101	99		98				72	I-band		93	S / 1
103	179571466	179571181	178706739	178706454	29135	29420	102	100		99				75	I-band		286	A / 2
104	179570084	179569901	178705357	178705174	29421	29604	103	101		100				76	I-band		184	A / 0
105	179569693	179569604	178704966	178704877	29605	29694	104	102		101				75	I-band		90	S / 0
106	179569504	179569237	178704777	178704510	29695	29962	105	103		102				70	I-band		268	A / 1
107	179569134	179568874	178704407	178704147	29963	30223	106	104		103				73	I-band		261	S / 1
108	179567390	179567181	178702663	178702454	30224	30433	107	105		104				74	I-band		210	S / 1
109	179566972	179566895	178702245	178702168	30434	30511	108	106		105				74	I-band		78	S / 1
110	179566793	179566767	178702066	178702040	30512	30538	109	107		106				74	I-band		27	S / 1
111	179566314	179566255	178701587	178701528	30539	30598	110	108		107				80	I-band		60	S / 1
112	179565930	179565847	178701203	178701120	30599	30682	111	109		108				82	I-band		84	S / 1
113	179563641	179563570	178698914	178698843	30683	30754	112	110		109				80	I-band		72	S / 1
114	179561895	179561848	178697168	178697121	30755	30802	113	111		110				75	I-band		48	S / 1
115	179560996	179560592	178696269	178695865	30803	31207	114	112		111				74	I-band		405	S / 1
116	179560137	179560075	178695410	178695348	31208	31270	115	113		112				75	I-band		63	S / 1
117	179559633	179559556	178694906	178694829	31271	31348	116	114		113				63	I-band		78	S / 1
118	179559403	179559326	178694676	178694599	31349	31426	117	115		114				59	I-band		78	S / 1
119	179558735	179558649	178694008	178693922	31427	31513	118	116		115				57	I-band		87	S / 1
120	179558416	179558336	178693689	178693609	31514	31594	119	117		116				56	I-band		81	S / 1
121	179557307	179557224	178692580	178692497	31595	31678	120	118		117				58	I-band		84	S / 1
122	179556826	179556743	178692099	178692016	31679	31762	121	119		118				54	I-band		84	S / 1
123	179554623	179554540	178689896	178689813	31763	31846	122	120		119				78	I-band		84	S / 1
124	179554322	179554242	178689595	178689515	31847	31927	123	121		120				22	I-band		81	S / 1
125	179554100	179554017	178689373	178689290	31928	32011	124	122		121				25	I-band		84	S / 1
126	179553863	179553780	178689136	178689053	32012	32095	125	123		122				15	I-band		84	S / 1
127	179553505	179553404	178688778	178688677	32096	32197	126	124		123				15	I-band		102	S / 1
128	179552951	179552838	178688224	178688111	32198	32311	127	125		124				28	I-band		114	S / 1
129	179550325	179550245	178685598	178685518	32312	32392	128	126		125				28	I-band		81	S / 1
130	179550057	179549980	178685330	178685253	32393	32470	129	127		126				9	I-band		78	S / 1
131	179549716	179549633	178684989	178684906	32471	32554	130	128		127				10	I-band		84	S / 1
132	179549476	179549393	178684749	178684666	32555	32638	131	129		128				6	I-band		84	S / 1
133	179549140	179549057	178684413	178684330	32639	32722	132	130		129				10	I-band		84	S / 1
134	179548809	179548726	178684082	178683999	32723	32806	133	131		130				12	I-band		84	S / 1
135	179548018	179547938	178683291	178683211	32807	32887	134	132		131				26	I-band		81	S / 1
136	179547630	179547424	178682903	178682697	32888	33094	135	133		132				76	I-band		207	S / 1
137	179546465	179546388	178681738	178681661	33095	33172	136	134		133				77	I-band		78	S / 1
138	179546177	179546103	178681450	178681376	33173	33247	137	135		134				4	I-band		75	S / 1
139	179545898	179545806	178681171	178681079	33248	33340	138	136		135				1	I-band		93	S / 1
140	179545058	179544981	178680331	178680254	33341	33418	139	137		136				1	I-band		78	S / 1
141	179544782	179544621	178680055	178679894	33419	33580	140	138		137				1	I-band		162	S / 1
142	179544409	179544326	178679682	178679599	33581	33664	141	139		138				1	I-band		84	S / 1
143	179544143	179544066	178679416	178679339	33665	33742	142	140		139				2	I-band		78	S / 1
144	179543557	179543474	178678830	178678747	33743	33826	143	141		140				74	I-band		84	S / 1
145	179543224	179543141	178678497	178678414	33827	33910	144	142		141				69	I-band		84	S / 1
146	179542935	179542852	178678208	178678125	33911	33994	145	143		142				68	I-band		84	S / 1
147	179542644	179542348	178677917	178677621	33995	34291	146	144		143				2	I-band		297	S / 1
148	179542014	179541928	178677287	178677201	34292	34378	147							2			87	S / 1
149	179540722	179540648	178675995	178675921	34379	34453	148	145		144				3	I-band		75	S / 1
150	179540481	179540398	178675754	178675671	34454	34537	149							1			84	S / 1
151	179539840	179539766	178675113	178675039	34538	34612	150	146		145				20	I-band		75	S / 1
152	179539136	179539041	178674409	178674314	34613	34708	151	147		146				54	I-band		96	S / 1
153	179538437	179538360	178673710	178673633	34709	34786	152	148		147				48	I-band		78	S / 1
154	179537430	179537362	178672703	178672635	34787	34855	153	149		148				10	I-band		69	S / 1
155	179537208	179537134	178672481	178672407	34856	34930	154	150		149				3	I-band		75	S / 1
156	179536994	179536698	178672267	178671971	34931	35227	155	151		150				2	I-band		297	S / 1
157	179535897	179535817	178671170	178671090	35228	35308	156	152		151				5	I-band		81	S / 1
158	179535022	179534945	178670295	178670218	35309	35386	157	153		152				30	I-band		78	S / 1
159	179534402	179534319	178669675	178669592	35387	35470	158							1			84	S / 1
160	179534174	179534100	178669447	178669373	35471	35545	159							1			75	S / 1
161	179532448	179532365	178667721	178667638	35546	35629	160							3			84	S / 1
162	179532252	179532169	178667525	178667442	35630	35713	161							2			84	S / 1
163	179532046	179531963	178667319	178667236	35714	35797	162							1			84	S / 1
164	179531628	179531551	178666901	178666824	35798	35875	163							0			78	S / 1
165	179530518	179530435	178665791	178665708	35876	35959	164							3			84	S / 1
166	179530187	179530104	178665460	178665377	35960	36043	165							3			84	S / 1
167	179529653	179529579	178664926	178664852	36044	36118	166							2			75	S / 1
168	179529464	179529381	178664737	178664654	36119	36202	167							3			84	S / 1
169	179529264	179529187	178664537	178664460	36203	36280	168							2			78	S / 1
170	179528825	179528742	178664098	178664015	36281	36364	169							2			84	S / 1
171	179528629	179528546	178663902	178663819	36365	36448	170							1			84	S / 1
172	179528437	179528354	178663710	178663627	36449	36532	171							1			84	S / 1
173	179528243	179528160	178663516	178663433	36533	36616	172							7			84	S / 1
174	179528076	179527993	178663349	178663266	36617	36700	173							3			84	S / 1
175	179527782	179527693	178663055	178662966	36701	36790	174	154		153				51	I-band		90	S / 1
176	179527539	179527456	178662812	178662729	36791	36874	175							1			84	S / 1
177	179527343	179527260	178662616	178662533	36875	36958	176							6			84	S / 1
178	179527145	179527065	178662418	178662338	36959	37039	177							2			81	S / 1
179	179526949	179526869	178662222	178662142	37040	37120	178							1			81	S / 1
180	179526755	179526675	178662028	178661948	37121	37201	179							5			81	S / 1
181	179526569	179526486	178661842	178661759	37202	37285	180							2			84	S / 1
182	179523982	179523899	178659255	178659172	37286	37369	181	155		154				8	I-band		84	S / 1
183	179523815	179523732	178659088	178659005	37370	37453	182	156		155				4	I-band		84	S / 1
184	179523521	179523432	178658794	178658705	37454	37543	183							22			90	S / 1
185	179523278	179523195	178658551	178658468	37544	37627	184							1			84	S / 1
186	179523082	179522999	178658355	178658272	37628	37711	185							7			84	S / 1
187	179522884	179522804	178658157	178658077	37712	37792	186							5			81	S / 1
188	179522688	179522608	178657961	178657881	37793	37873	187							3			81	S / 1
189	179522494	179522414	178657767	178657687	37874	37954	188							7			81	S / 1
190	179522308	179522225	178657581	178657498	37955	38038	189							3			84	S / 1
191	179519722	179519639	178654995	178654912	38039	38122	190							4			84	S / 1
192	179519555	179519472	178654828	178654745	38123	38206	191							2			84	S / 1
193	179519261	179519172	178654534	178654445	38207	38296	192							13			90	S / 1
194	179519018	179518935	178654291	178654208	38297	38380	193							0			84	S / 1
195	179518822	179518739	178654095	178654012	38381	38464	194							5			84	S / 1
196	179518624	179518544	178653897	178653817	38465	38545	195							3			81	S / 1
197	179518428	179518348	178653701	178653621	38546	38626	196							2			81	S / 1
198	179518234	179518154	178653507	178653427	38627	38707	197							7			81	S / 1
199	179518048	179517965	178653321	178653238	38708	38791	198							3			84	S / 1
200	179517851	179517768	178653124	178653041	38792	38875	199							2			84	S / 1
201	179517658	179517575	178652931	178652848	38876	38959	200							0			84	S / 1
202	179517463	179517380	178652736	178652653	38960	39043	201							0			84	S / 1
203	179517268	179517185	178652541	178652458	39044	39127	202	157		156				3	I-band		84	S / 1
204	179517074	179516991	178652347	178652264	39128	39211	203	158		157				8	I-band		84	S / 1
205	179516906	179516823	178652179	178652096	39212	39295	204	159		158				6	I-band		84	S / 1
206	179516694	179516611	178651967	178651884	39296	39379	205	160		159				5	I-band		84	S / 1
207	179516476	179516393	178651749	178651666	39380	39463	206	161		160				8	I-band		84	S / 1
208	179516263	179516180	178651536	178651453	39464	39547	207	162		161				9	I-band		84	S / 1
209	179516047	179515970	178651320	178651243	39548	39625	208	163		162				10	I-band		78	S / 1
210	179515561	179515478	178650834	178650751	39626	39709	209	164		163				7	I-band		84	S / 1
211	179514998	179514891	178650271	178650164	39710	39817	210	165		164				7	I-band		108	S / 1
212	179514621	179514544	178649894	178649817	39818	39895	211	166		165				8	I-band		78	S / 1
213	179514358	179514281	178649631	178649554	39896	39973	212							3			78	S / 1
214	179514058	179513975	178649331	178649248	39974	40057	213							2			84	S / 1
215	179512191	179512108	178647464	178647381	40058	40141	214							2			84	S / 1
216	179511871	179511791	178647144	178647064	40142	40222	215							1			81	S / 1
217	179511286	179511212	178646559	178646485	40223	40297	216							1			75	S / 1
218	179510757	179510647	178646030	178645920	40298	40408	217	167		166				3	I-band		111	S / 1
219	179509343	179509275	178644616	178644548	40409	40477	218	168		167				4	I-band		69	S / 1
220	179507044	179506964	178642317	178642237	40478	40558	219	169	47	168	48	48		100	I-band		81	S / 1
221	179506042	179505968	178641315	178641241	40559	40633	220	170	48	169	49	49		100	I-band		75	S / 1
222	179505357	179505268	178640630	178640541	40634	40723	221	171	49	170	50	50		100	I-band		90	S / 1
223	179504837	179504775	178640110	178640048	40724	40786	222	172	50	171	51	51		100	I-band		63	S / 1
224	179504515	179504426	178639788	178639699	40787	40876	223	173	51	172	52	52		100	I-band		90	S / 1
225	179502146	179502096	178637419	178637369	40877	40927	224	174	52	173	53	53		79	I-band		51	S / 1
226	179501526	179501125	178636799	178636398	40928	41329	225	175	53	174	54	54		100	I-band		402	S / 1
227	179500968	179500690	178636241	178635963	41330	41608	226	176	54	175	55	55		100	I-band		279	S / 1
228	179500442	179500167	178635715	178635440	41609	41884	227	177	55	176	56	56		100	I-band		276	S / 1
229	179500031	179499892	178635304	178635165	41885	42024	228	178	56	177	57	57		100	I-band		140	A / 0
230	179499576	179499450	178634849	178634723	42025	42151	229	179	57	178	58	58		100	I-band		127	A / 1
231	179499356	179499093	178634629	178634366	42152	42415	230	180	58	179	59	59		100	I-band		264	S / 1
232	179498810	179498544	178634083	178633817	42416	42682	231	181	59	180	60	60		100	I-band		267	S / 1
233	179498403	179498140	178633676	178633413	42683	42946	232	182	60	181	61	61		100	I-band		264	S / 1
234	179498053	179497914	178633326	178633187	42947	43086	233	183	61	182	62	62		100	I-band		140	A / 0
235	179497771	179497645	178633044	178632918	43087	43213	234	184	62	183	63	63		100	I-band		127	A / 1
236	179497519	179497253	178632792	178632526	43214	43480	235	185	63	184	64	64		100	I-band		267	S / 1
237	179497140	179496874	178632413	178632147	43481	43747	236	186	64	185	65	65		100	I-band		267	S / 1
238	179496027	179495761	178631300	178631034	43748	44014	237	187	65	186	66	66		100	I-band		267	S / 1
239	179495670	179495531	178630943	178630804	44015	44154	238	188	66	187	67	67		100	I-band		140	A / 0
240	179495094	179494968	178630367	178630241	44155	44281	239	189	67	188	68	68		100	I-band		127	A / 1
241	179494170	179494028	178629443	178629301	44282	44424	240	190	68	189	69	69		100	I-band		143	A / 0
242	179490123	179490000	178625396	178625273	44425	44548	241	191	69	190	70	70		100	I-band		124	A / 1
243	179489458	179489192	178624731	178624465	44549	44815	242	192	70	191	71	71		59	I-band		267	S / 1
244	179487494	179487397	178622767	178622670	44816	44913	243	193	71	192	72	72		100	I-band		98	A / 0
245	179486735	179486567	178622008	178621840	44914	45082	244	194	72	193	73	73		100	I-band		169	A / 1
246	179486468	179486202	178621741	178621475	45083	45349	245	195	73	194	74	74		100	I-band		267	S / 1
247	179486095	179485829	178621368	178621102	45350	45616	246	196	74	195	75	75		100	I-band		267	S / 1
248	179485720	179485442	178620993	178620715	45617	45895	247	197	75	196	76	76		100	I-band		279	S / 1
249	179485352	179484944	178620625	178620217	45896	46304	248	198	76	197	77	77		100	I-band		409	A / 2
250	179484839	179484715	178620112	178619988	46305	46429	249	199	77	198	78	78		100	I-band		125	A / 1
251	179484614	179484348	178619887	178619621	46430	46696	250	200	78	199	79	79		100	I-band		267	S / 1
252	179483580	179483311	178618853	178618584	46697	46966	251	201	79	200	80	80		100	I-band		270	S / 1
253	179483218	179482916	178618491	178618189	46967	47269	252	202	80	201	81	81		100	A-band		303	S / 1
254	179482808	179482506	178618081	178617779	47270	47572	253	203	81	202	82	82		100	A-band		303	S / 1
255	179482239	179482052	178617512	178617325	47573	47760	254	204	82	203	83	83		100	A-band		188	A / 0
256	179481961	179481847	178617234	178617120	47761	47875	255	205	83	204	84	84		100	A-band		115	A / 1
257	179481740	179481456	178617013	178616729	47876	48160	256	206	84	205	85	85		100	A-band		285	S / 1
258	179481357	179481206	178616630	178616479	48161	48312	257	207	85	206	86	86		100	A-band		152	A / 0
259	179480515	179480368	178615788	178615641	48313	48460	258	208	86	207	87	87		100	A-band		148	A / 1
260	179480211	179480034	178615484	178615307	48461	48638	259	209	87	208	88	88		100	A-band		178	A / 2
261	179479695	179479574	178614968	178614847	48639	48760	260	210	88	209	89	89		100	A-band		122	A / 1
262	179479480	179479193	178614753	178614466	48761	49048	261	211	89	210	90	90		100	A-band		288	S / 1
263	179479075	179478779	178614348	178614052	49049	49345	262	212	90	211	91	91		100	A-band		297	S / 1
264	179478664	179478478	178613937	178613751	49346	49532	263	213	91	212	92	92		100	A-band		187	A / 2
265	179478003	179477888	178613276	178613161	49533	49648	264	214	92	213	93	93		100	A-band		116	A / 1
266	179477799	179477500	178613072	178612773	49649	49948	265	215	93	214	94	94		100	A-band		300	S / 1
267	179477303	179477004	178612576	178612277	49949	50248	266	216	94	215	95	95		100	A-band		300	S / 1
268	179476889	179476784	178612162	178612057	50249	50354	267	217	95	216	96	96		100	A-band		106	A / 2
269	179476681	179476485	178611954	178611758	50355	50551	268	218	96	217	97	97		100	A-band		197	A / 1
270	179476404	179476099	178611677	178611372	50552	50857	269	219	97	218	98	98		100	A-band		306	S / 1
271	179475998	179475720	178611271	178610993	50858	51136	270	220	98	219	99	99		100	A-band		279	S / 1
272	179475116	179474817	178610389	178610090	51137	51436	271	221	99	220	100	100		100	A-band		300	S / 1
273	179474713	179474411	178609986	178609684	51437	51739	272	222	100	221	101	101		100	A-band		303	S / 1
274	179474297	179473935	178609570	178609208	51740	52102	273	223	101	222	102	102		100	A-band		363	S / 1
275	179473635	179473333	178608908	178608606	52103	52405	274	224	102	223	103	103		100	A-band		303	S / 1
276	179473204	179472905	178608477	178608178	52406	52705	275	225	103	224	104	104		100	A-band		300	S / 1
277	179472808	179472512	178608081	178607785	52706	53002	276	226	104	225	105	105		100	A-band		297	S / 1
278	179472412	179472128	178607685	178607401	53003	53287	277	227	105	226	106	106		100	A-band		285	S / 1
279	179472041	179471748	178607314	178607021	53288	53581	278	228	106	227	107	107		100	A-band		294	S / 1
280	179470440	179470141	178605713	178605414	53582	53881	279	229	107	228	108	108		100	A-band		300	S / 1
281	179470022	179469714	178605295	178604987	53882	54190	280	230	108	229	109	109		100	A-band		309	S / 1
282	179469625	179469435	178604898	178604708	54191	54381	281	231	109	230	110	110		100	A-band		191	A / 0
283	179469032	179468603	178604305	178603876	54382	54811	282	232	110	231	111	111		100	A-band		430	A / 1
284	179467317	179467009	178602590	178602282	54812	55120	283	233	111	232	112	112		100	A-band		309	S / 1
285	179466877	179466729	178602150	178602002	55121	55269	284	234	112	233	113	113		100	A-band		149	A / 0
286	179466641	179466609	178601914	178601882	55270	55302	285	235	113	234	114	114		100	A-band		33	S / 0
287	179466514	179466385	178601787	178601658	55303	55432	286	236	114	235	115	115		100	A-band		130	A / 1
288	179466291	179465992	178601564	178601265	55433	55732	287	237	115	236	116	116		100	A-band		300	S / 1
289	179465898	179465581	178601171	178600854	55733	56050	288	238	116	237	117	117		100	A-band		318	S / 1
290	179464577	179464281	178599850	178599554	56051	56347	289	239	117	238	118	118		100	A-band		297	S / 1
291	179464172	179463873	178599445	178599146	56348	56647	290	240	118	239	119	119		100	A-band		300	S / 1
292	179463789	179463475	178599062	178598748	56648	56962	291	241	119	240	120	120		100	A-band		315	S / 1
293	179463381	179463233	178598654	178598506	56963	57111	292	242	120	241	121	121		100	A-band		149	A / 0
294	179462785	179462635	178598058	178597908	57112	57262	293	243	121	242	122	122		100	A-band		151	A / 1
295	179462546	179462265	178597819	178597538	57263	57544	294	244	122	243	123	123		100	A-band		282	S / 1
296	179460536	179460234	178595809	178595507	57545	57847	295	245	123	244	124	124		100	A-band		303	S / 1
297	179459373	179459071	178594646	178594344	57848	58150	296	246	124	245	125	125		100	A-band		303	S / 1
298	179458969	179458688	178594242	178593961	58151	58432	297	247	125	246	126	126		100	A-band		282	S / 1
299	179458594	179458295	178593867	178593568	58433	58732	298	248	126	247	127	127		100	A-band		300	S / 1
300	179458202	179457900	178593475	178593173	58733	59035	299	249	127	248	128	128		100	A-band		303	S / 1
301	179457810	179457502	178593083	178592775	59036	59344	300	250	128	249	129	129		100	A-band		309	S / 1
302	179457387	179457106	178592660	178592379	59345	59626	301	251	129	250	130	130		100	A-band		282	S / 1
303	179457004	179456705	178592277	178591978	59627	59926	302	252	130	251	131	131		100	A-band		300	S / 1
304	179456619	179456326	178591892	178591599	59927	60220	303	253	131	252	132	132		100	A-band		294	S / 1
305	179456231	179453265	178591504	178588538	60221	63187	304	254	132	253	133	133		100	A-band		2967	S / 1
306	179452946	179452626	178588219	178587899	63188	63508	305	255	133	254	134	134		100	A-band		321	S / 1
307	179452527	179452243	178587800	178587516	63509	63793	306	256	134	255	135	135		100	A-band		285	S / 1
308	179452144	179451845	178587417	178587118	63794	64093	307	257	135	256	136	136		100	A-band		300	S / 1
309	179451534	179451232	178586807	178586505	64094	64396	308	258	136	257	137	137		100	A-band		303	S / 1
310	179450074	179449799	178585347	178585072	64397	64672	309	259	137	258	138	138		100	A-band		276	S / 1
311	179449695	179449396	178584968	178584669	64673	64972	310	260	138	259	139	139		100	A-band		300	S / 1
312	179449305	179449003	178584578	178584276	64973	65275	311	261	139	260	140	140		100	A-band		303	S / 1
313	179448633	179448334	178583906	178583607	65276	65575	312	262	140	261	141	141		100	A-band		300	S / 1
314	179447954	179447667	178583227	178582940	65576	65863	313	263	141	262	142	142		100	A-band		288	S / 1
315	179447319	179447023	178582592	178582296	65864	66160	314	264	142	263	143	143		100	A-band		297	S / 1
316	179446935	179446633	178582208	178581906	66161	66463	315	265	143	264	144	144		100	A-band		303	S / 1
317	179446531	179446226	178581804	178581499	66464	66769	316	266	144	265	145	145		100	A-band		306	S / 1
318	179445336	179445049	178580609	178580322	66770	67057	317	267	145	266	146	146		100	A-band		288	S / 1
319	179444956	179444666	178580229	178579939	67058	67348	318	268	146	267	147	147		100	A-band		291	S / 1
320	179444575	179444288	178579848	178579561	67349	67636	319	269	147	268	148	148		100	A-band		288	S / 1
321	179444120	179443533	178579393	178578806	67637	68224	320	270	148	269	149	149		100	A-band		588	S / 1
322	179443442	179443338	178578715	178578611	68225	68329	321	271	149	270	150	150		100	A-band		105	S / 1
323	179442912	179442715	178578185	178577988	68330	68527	322	272	150	271	151	151		100	A-band		198	S / 1
324	179442625	179442329	178577898	178577602	68528	68824	323	273	151	272	152	152		100	A-band		297	S / 1
325	179442237	179441650	178577510	178576923	68825	69412	324	274	152	273	153	153		100	A-band		588	S / 1
326	179441558	179441256	178576831	178576529	69413	69715	325	275	153	274	154	154		100	A-band		303	S / 1
327	179441143	179424038	178576416	178559311	69716	86821	326	276	154	275	155	155		100	A-band		17106	S / 1
328	179423364	179423068	178558637	178558341	86822	87118	327	277	155	276	156	156		100	A-band		297	S / 1
329	179422962	179422375	178558235	178557648	87119	87706	328	278	156	277	157	157		100	A-band		588	S / 1
330	179422282	179421980	178557555	178557253	87707	88009	329	279	157	278	158	158		100	A-band		303	S / 1
331	179421871	179421575	178557144	178556848	88010	88306	330	280	158	279	159	159		100	A-band		297	S / 1
332	179419879	179419592	178555152	178554865	88307	88594	331	281	159	280	160	160		100	A-band		288	S / 1
333	179419479	179419180	178554752	178554453	88595	88894	332	282	160	281	161	161		100	A-band		300	S / 1
334	179418943	179418641	178554216	178553914	88895	89197	333	283	161	282	162	162		100	A-band		303	S / 1
335	179418534	179418229	178553807	178553502	89198	89503	334	284	162	283	163	163		100	A-band		306	S / 1
336	179418123	179416357	178553396	178551630	89504	91270	335	285	163	284	164	164		100	A-band		1767	S / 1
337	179415987	179415694	178551260	178550967	91271	91564	336	286	164	285	165	165		100	A-band		294	S / 1
338	179415000	179414713	178550273	178549986	91565	91852	337	287	165	286	166	166		100	A-band		288	S / 1
339	179414596	179414297	178549869	178549570	91853	92152	338	288	166	287	167	167		100	A-band		300	S / 1
340	179414200	179412134	178549473	178547407	92153	94219	339	289	167	288	168	168		100	A-band		2067	S / 1
341	179412032	179411730	178547305	178547003	94220	94522	340	290	168	289	169	169		100	A-band		303	S / 1
342	179411632	179411327	178546905	178546600	94523	94828	341	291	169	290	170	170		100	A-band		306	S / 1
343	179411229	179410939	178546502	178546212	94829	95119	342	292	170	291	171	171		100	A-band		291	S / 1
344	179410843	179410547	178546116	178545820	95120	95416	343	293	171	292	172	172		100	A-band		297	S / 1
345	179410420	179410115	178545693	178545388	95417	95722	344	294	172	293	173	173		100	A-band		306	S / 1
346	179409233	179408928	178544506	178544201	95723	96028	345	295	173	294	174	174		100	A-band		306	S / 1
347	179408842	179408561	178544115	178543834	96029	96310	346	296	174	295	175	175		100	A-band		282	S / 1
348	179408389	179407796	178543662	178543069	96311	96904	347	297	175	296	176	176		100	A-band		594	S / 1
349	179407676	179407389	178542949	178542662	96905	97192	348	298	176	297	177	177		100	A-band		288	S / 1
350	179407290	179406991	178542563	178542264	97193	97492	349	299	177	298	178	178		100	A-band		300	S / 1
351	179406311	179406009	178541584	178541282	97493	97795	350	300	178	299	179	179		100	A-band		303	S / 1
352	179405097	179404795	178540370	178540068	97796	98098	351	301	179	300	180	180		100	A-band		303	S / 1
353	179404693	179404109	178539966	178539382	98099	98683	352	302	180	301	181	181		100	A-band		585	S / 1
354	179403978	179403673	178539251	178538946	98684	98989	353	303	181	302	182	182		100	A-band		306	S / 1
355	179403566	179403267	178538839	178538540	98990	99289	354	304	182	303	183	183		100	A-band		300	S / 1
356	179402644	179402069	178537917	178537342	99290	99865	355	305	183	304	184	184		100	A-band		576	S / 1
357	179401970	179401665	178537243	178536938	99866	100171	356	306	184	305	185	185		100	A-band		306	S / 1
358	179401302	179400709	178536575	178535982	100172	100765	357	307	185	306	186	186		100	A-band		594	S / 1
359	179400576	179394968	178535849	178530241	100766	106374	358	308	186	307	187	187		100	M-band		5609	A / 0
360	179394843	179394687	178530116	178529960	106375	106531	359	309	187	308	188	188		100	M-band		157	A / 1
361	179393946	179393255	178529219	178528528	106532	107223	360	310	188	309	189	189		100	M-band		692	A / 0
362	179393154	179393001	178528427	178528274	107224	107377	361	311	189	310	190	190		100	M-band		154	A / 1
363	179392475	179392173	178527748	178527446	107378	107680	362	312	190	311	191	191		99	M-band		303	S / 1
364	179392034	179390716	178527307	178525989	107681	107976	363	313	191	312	192	192		100	M-band		296	A / -

1 The exon number is the LRG numbering (also adopted by the LOVD) - this is recommended for clinical reporting. All exons are numbered sequentially along the chromosome. Please note this is not the same as the RefSeq numbering.

2 PSI - percentage spliced in: a measure of splicing derived from RNAseq, this is an estimate of the percentage of TTN transcripts that incorporate a given exon. 100% implies a constitutively expressed exon. The data shown represent exon usage in the human left ventricle, derived from patients with DCM.

3 Symmetry: S = symmetric (the exon length in base pairs is a multiple of 3), A = asymmetric.
Phase - the phase indicates the position of an intron relative to the amino sequence: 0 = between codons, 1 = between the 1st and 2nd base, 2 = between the 2nd and 3rd base. The phase shown in this table is the end phase for each exon, i.e. the phase of the intron after the exon.

4 As exon 48 of the Novex-3 transcript is a 3' exon, the PSI is unreliable. An alternative method comparing ratio of reads from exons 48 & 364 suggests novex-3 represents 9.4% of transcripts in the DCM cohort and 7.3% of transcripts for GTEx.

5 The Hg38 start and Hg38 positions have been generated by lifting over Hg19 start and Hg19 end positions using the UCSC liftOver software with the appropriate chain files from liftOver